Triplex-forming molecules: from concepts to applications

Triplex-forming molecules: from concepts to applications

Autor Faria, M. Google Scholar
Giovannangeli, C. Google Scholar
Instituição Museum Natl Hist Nat
Universidade Federal de São Paulo (UNIFESP)
Resumo The ability to specifically manipulate gene expression has wide-ranging applications in experimental biology and in gene-based therapeutics. the design of molecules that recognise specific sequences on the DNA double helix provides us with interesting tools to interfere with DNA information processing at an early stage of gene expression. Triplex-forming molecules specifically recognise oligopyrimidine-oligopurine sequences by hydrogen bonding interactions. Applications of such triplex-forming molecules (TFMs) are the subject of the present review. in cell cultures, TFMs have been successfully used to down- or up-regulate transcription in a gene-specific manner and to induce genomic DNA modifications at a selected site. the first evidence of a triplex-based activity in animals has been provided recently. in TFMs are also powerful tools for gene-specific chemistry, in addition particular for gene transfer applications. Copyright (C) 2001 John Wiley & Sons, Ltd.
Palavra-chave triple helix
peptide nucleic acid (PNA)
transcription
recombination
Idioma Inglês
Data de publicação 2001-07-01
Publicado em Journal of Gene Medicine. W Sussex: John Wiley & Sons Ltd, v. 3, n. 4, p. 299-310, 2001.
ISSN 1099-498X (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 299-310
Fonte http://dx.doi.org/10.1002/jgm.192
Direito de acesso Acesso restrito
Tipo Resenha
Web of Science WOS:000170474400001
Endereço permanente http://repositorio.unifesp.br/handle/11600/26587

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