Acute effect of nasal continuous positive air pressure on the ventilatory control of patients with obstructive sleep apnea

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dc.contributor.author Moura, SMT
dc.contributor.author Bittencourt, L. R.
dc.contributor.author Bagnato, M. C.
dc.contributor.author Lucas, SR
dc.contributor.author Tufik, S.
dc.contributor.author Nery, L. E.
dc.date.accessioned 2016-01-24T12:31:23Z
dc.date.available 2016-01-24T12:31:23Z
dc.date.issued 2001-05-01
dc.identifier http://dx.doi.org/10.1159/000050505
dc.identifier.citation Respiration. Basel: Karger, v. 68, n. 3, p. 243-249, 2001.
dc.identifier.issn 0025-7931
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/26548
dc.description.abstract Background: Sleep fragmentation can decrease the awake ventilatory control. Since patients with obstructive sleep apnea (OSA) patients exhibit sleep fragmentation linked to respiratory events, their ventilatory control could be impaired. However, most of these patients are also obese, which could conversely increase the ventilatory control. the effect of nasal continuous positive airway pressure (CPAP) on the awake ventilatory control in normocapnic OSA patients is unclear. Objectives: To study the acute effect of nasal CPAP on the awake ventilatory control in normocapnic OSA patients. Methods: 12 normocapnic OSA patients, with an apnea/hypopnea index (AHI) >15 with moderate obesity (body mass index: 33.5 kg/m(2)) and normal pulmonary function tests were submitted to two polysomnography studies (diagnostic and for CPAP titration). Before and after 3 consecutive nights of nasal CPAP we analyzed the hypersomnia score and the ventilatory and the mouth occlusion pressure (P.(1)) responses at rest (breathing room air and a mixture of 8% CO2 + 40% O-2) Results: the respiratory drive of OSA patients as evaluated by P.(1) was in the range of the controls of our laboratory. After nasal CPAP, a significant decrease in AHI (mean: 51.9-9.4/h) and arousal (mean: 88.7-43/h) occurred, as well as improve ment in nocturnal oxyhemoglobin. There was a marginal increase in DeltaV(E)/DeltaP(ET)CO(2) (mean: 1.41-1.87 liters/min/mm Hg, p = 0.09) and a significant rise in P .(1)/DeltaP(ET)CO(2) (mean: 0.29-0.43 cm H2O/mm Hg), a better indicator of ventilatory drive. Conclusions: Normocapnic OSA patients increased their awake ventilatory drive response to a hypercapnic and hyperoxic mixture with the use of 3 consecutive nights of nasal CPAP. Copyright (C) 2001 S. Karger AG, Basel. en
dc.format.extent 243-249
dc.language.iso eng
dc.publisher Karger
dc.relation.ispartof Respiration
dc.rights Acesso restrito
dc.subject obstructive sleep apnea en
dc.subject ventilatory drive en
dc.subject hypersomnia en
dc.subject nasal continuous positive air pressure en
dc.subject obesity en
dc.title Acute effect of nasal continuous positive air pressure on the ventilatory control of patients with obstructive sleep apnea en
dc.type Artigo
dc.rights.license http://www.karger.com/Services/RightsPermissions
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Div Pulm, BR-04023062 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Psychobiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Pulm, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psychobiol, BR-04023062 São Paulo, Brazil
dc.identifier.doi 10.1159/000050505
dc.description.source Web of Science
dc.identifier.wos WOS:000169289500004



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