Age-dependent consequences of seizures and the development of temporal lobe epilepsy in the rat

Age-dependent consequences of seizures and the development of temporal lobe epilepsy in the rat

Autor Dube, C. Google Scholar
Fernandes, MJDS Google Scholar
Nehlig, A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Univ Strasbourg 1
Resumo The age-related functional changes underlying epileptogenesis remain to be clarified. in the present study, we explored the correlation between metabolic changes, neuronal damage and epileptogenesis during the acute, silent and chronic phases following status epilepticus (SE) induced by lithium-pilocarpine (Li-Pilo) in 10- (P10), 21-day-old (P21) and adult rats. Local cerebral metabolic rates for glucose (LCMRglcs) were measured by the [C-14]2-deoxyglucose method during SE, the silent period and the interictal phase of the chronic period. Neurodegeneration was assessed by cresyl violet staining. During SE, LCMRglcs dramatically increased at all ages mainly in forebrain vulnerable regions. During the silent phase, in P21 and adult rats, metabolic decreases were recorded in damaged forebrain regions involved in the genesis and propagation of seizures 14 days after SE. At the end of the silent phase, P21 and adult rats exhibited metabolic increases in intact brainstem areas involved in the remote control of epilepsy. During the interictal phase of the chronic period, LCMRglcs decreased in damaged forebrain areas of adult and P21 rats that were not spontaneously epileptic, while LCMRglcs were similar to control levels in epileptic P21 rats. in P10 rats, there was no damage and no metabolic consequences at any time after SE. in conclusion, the process of epileptogenesis and its functional consequences differ in P21 and adult rats. the factors underlying these age-related differences remain to be explored. Copyright (C) 2001 S. Karger AG, Basel.
Palavra-chave brain development
cerebral glucose
epilepsy
glucose metabolism
rat
temporal lobe
Idioma Inglês
Data de publicação 2001-05-01
Publicado em Developmental Neuroscience. Basel: Karger, v. 23, n. 3, p. 219-223, 2001.
ISSN 0378-5866 (Sherpa/Romeo, fator de impacto)
Publicador Karger
Extensão 219-223
Fonte http://dx.doi.org/10.1159/000046147
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000171875500011
Endereço permanente http://repositorio.unifesp.br/handle/11600/26547

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