The mucin-like glycoprotein super-family of Trypanosoma cruzi: structure and biological roles

The mucin-like glycoprotein super-family of Trypanosoma cruzi: structure and biological roles

Autor Acosta-Serrano, A. Google Scholar
Almeida, I. C. Google Scholar
Freitas, L. H. Google Scholar
Yoshida, N. Google Scholar
Schenkman, S. Google Scholar
Instituição Johns Hopkins Univ
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo Trypanosoma cruzi expresses at its surface large amounts of mucin-like glycoproteins. the T. cruzi mucins (TcMUC), a group of highly glycosylated GPI-anchored proteins rich in Thr, Ser, and Pro residues, are expressed in high copy numbers in both insect and mammalian stages of the parasite. These molecules are encoded by a multigene family and contain a unique type of glycosylation consisting of several sialylated O-glycans linked to the protein backbone via Nw-acetylglucosamine residues. the TcMUC are important because of their role in host cell invasion and the ability to induce secretion of proinflammatory cytokines and nitric oxide in activated macrophages. the TcMUC are also significant in being the major substrate for the cell surface trans-sialidase. in this review, we summarize the recent knowledge on the molecular structure and function of this family of T. cruzi glycoproteins. (C) 2001 Elsevier Science B.V. All rights reserved.
Palavra-chave Trypanosoma cruzi
mucins
sialic acid
trans-sialidase
GPI
glycosylation
Idioma Inglês
Data de publicação 2001-05-01
Publicado em Molecular and Biochemical Parasitology. Amsterdam: Elsevier B.V., v. 114, n. 2, p. 143-150, 2001.
ISSN 0166-6851 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 143-150
Fonte http://dx.doi.org/10.1016/S0166-6851(01)00245-6
Direito de acesso Acesso restrito
Tipo Resenha
Web of Science WOS:000168924900002
Endereço permanente http://repositorio.unifesp.br/handle/11600/26542

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