Effects of formaldehyde on the frog's mucociliary epithelium as a surrogate to evaluate air pollution effects on the respiratory epithelium

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dc.contributor.author Flo-Neyret, Claudia
dc.contributor.author Lorenzi-Filho, Geraldo
dc.contributor.author Macchione, Mariangela
dc.contributor.author Garcia, Maria Lucia Bueno
dc.contributor.author Saldiva, Paulo Hilário Nascimento [UNIFESP]
dc.date.accessioned 2016-01-24T12:31:22Z
dc.date.available 2016-01-24T12:31:22Z
dc.date.issued 2001-05-01
dc.identifier http://dx.doi.org/10.1590/S0100-879X2001000500012
dc.identifier.citation Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 34, n. 5, p. 639-643, 2001.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/26538
dc.description.abstract The increasing use of alcohol as an alternative fuel to gasoline or diesel can increase emission of formaldehyde, an organic gas that is irritant to the mucous membranes. the respiratory system is the major target of air pollutants and its major defense mechanism depends on the continuous activity of the cilia and the resulting constant transportation of mucous secretion. the present study was designed to evaluate the effects of formaldehyde on the ciliated epithelium through a relative large dose range around the threshold limit value adopted by the Brazilian legislation, namely 1.6 ppm (1.25 to 5 ppm). for this pur pose, the isolated frog palate preparation was used as the target of toxic injury. Four groups of frog palates were exposed to diluted Ringer solution (control, N = 8) and formaldehyde diluted in Ringer solution at three different concentrations (1.25, 2.5 and 5.0 ppm, N = 10 for each group). Mucociliary clearance and ciliary beat frequency decreased significantly in contact with formaldehyde at the concentrations of 2.5 and 5.0 ppm after 60 min of exposure (P <0.05). We conclude that relatively low concentrations of formaldehyde, which is even below the Brazilian threshold limit value, are sufficient to cause short-term mucociliary impairment. en
dc.format.extent 639-643
dc.language.iso eng
dc.publisher Assoc Bras Divulg Cientifica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject mucociliary clearance en
dc.subject formaldehyde en
dc.subject air pollution en
dc.title Effects of formaldehyde on the frog's mucociliary epithelium as a surrogate to evaluate air pollution effects on the respiratory epithelium en
dc.type Artigo
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation USP, Fac Med, Dept Patol, Lab Poluicao Atmosfer Exptl, BR-01246903 São Paulo, Brazil
dc.description.affiliation USP, Fac Med, Disciplina Pneumol, Dept Cardiopneumol, BR-01246903 São Paulo, Brazil
dc.description.affiliation USP, Fac Med, Serv Clin Geral, Div Clin Med,Hosp Clin, BR-01246903 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Programa Pos Grad Reabilitacao, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Programa Pos Grad Reabilitacao, São Paulo, Brazil
dc.identifier.scielo S0100-879X2001000500012
dc.identifier.doi 10.1590/S0100-879X2001000500012
dc.description.source Web of Science
dc.identifier.wos WOS:000168735900012



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