Effects of formaldehyde on the frog's mucociliary epithelium as a surrogate to evaluate air pollution effects on the respiratory epithelium

Effects of formaldehyde on the frog's mucociliary epithelium as a surrogate to evaluate air pollution effects on the respiratory epithelium

Autor Flo-Neyret, Claudia Google Scholar
Lorenzi-Filho, Geraldo Google Scholar
Macchione, Mariangela Google Scholar
Garcia, Maria Lucia Bueno Google Scholar
Saldiva, Paulo Hilário Nascimento Autor UNIFESP Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo The increasing use of alcohol as an alternative fuel to gasoline or diesel can increase emission of formaldehyde, an organic gas that is irritant to the mucous membranes. the respiratory system is the major target of air pollutants and its major defense mechanism depends on the continuous activity of the cilia and the resulting constant transportation of mucous secretion. the present study was designed to evaluate the effects of formaldehyde on the ciliated epithelium through a relative large dose range around the threshold limit value adopted by the Brazilian legislation, namely 1.6 ppm (1.25 to 5 ppm). for this pur pose, the isolated frog palate preparation was used as the target of toxic injury. Four groups of frog palates were exposed to diluted Ringer solution (control, N = 8) and formaldehyde diluted in Ringer solution at three different concentrations (1.25, 2.5 and 5.0 ppm, N = 10 for each group). Mucociliary clearance and ciliary beat frequency decreased significantly in contact with formaldehyde at the concentrations of 2.5 and 5.0 ppm after 60 min of exposure (P <0.05). We conclude that relatively low concentrations of formaldehyde, which is even below the Brazilian threshold limit value, are sufficient to cause short-term mucociliary impairment.
Palavra-chave mucociliary clearance
formaldehyde
air pollution
Idioma Inglês
Data de publicação 2001-05-01
Publicado em Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 34, n. 5, p. 639-643, 2001.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Assoc Bras Divulg Cientifica
Extensão 639-643
Fonte http://dx.doi.org/10.1590/S0100-879X2001000500012
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000168735900012
SciELO S0100-879X2001000500012 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/26538

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