Autoimmune keratolysis in a patient with leukocytoclastic vasculitis - Unusual erythema elevatum diutinum with granulomatous pattern

Autoimmune keratolysis in a patient with leukocytoclastic vasculitis - Unusual erythema elevatum diutinum with granulomatous pattern

Autor Casanova, FHC Google Scholar
Meirelles, R. L. Google Scholar
Tojar, M. Google Scholar
Martins, M. C. Google Scholar
Rigueiro, M. P. Google Scholar
Freitas, D. de Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Purpose. Leukocytoclastic vasculitis (LCCV) is an immune complex-mediated, small vessel disease that is clinically characterized by the presence of palpable purpuric lesions, most often in association with rheumatic diseases. Ocular manifestations of LCCV are rare. Methods. We describe a patient with an unusual granulomatous pattern of erythema elevatum diutinum (EED) associated with autoimmune keratolysis. Results. We studied a 64-year-old man with decreased visual acuity and nodular lesions in both hands. Ocular examination revealed bilateral superior corneal melting with perforation in the left eye and conjunctival thickening in both eyes, in association with a severe inflammatory reaction. Histopathologic examination of the conjunctiva revealed granulomatous vasculitis with neutrophilic infiltrate, giant cells, and fibroblastic proliferation. A punch biopsy taken from his skin showed similar characteristics that suggested EED; however, there were no giant cells. Conclusion, To our knowledge, autoimmune keratolysis secondary to cutaneous LCCV (EED) has not been described previously, and there has been no description of granulomatous reaction (in the conjunctiva) in EED.
Palavra-chave leukocytoclastic vasculitis
keratolysis
erythema elevatum diutinum
ocular perforation
Idioma Inglês
Data de publicação 2001-04-01
Publicado em Cornea. Philadelphia: Lippincott Williams & Wilkins, v. 20, n. 3, p. 329-332, 2001.
ISSN 0277-3740 (Sherpa/Romeo, fator de impacto)
Publicador Lippincott Williams & Wilkins
Extensão 329-332
Fonte http://dx.doi.org/10.1097/00003226-200104000-00018
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000167643000018
Endereço permanente http://repositorio.unifesp.br/handle/11600/26522

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta