Cell-cycle kinetics of cell lines from patients with chromosomal mosaicism

Cell-cycle kinetics of cell lines from patients with chromosomal mosaicism

Autor Bortolai, A. Google Scholar
Melaragno, M. I. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Lymphocyte cultures from five patients with chromosomal mosaicism (two 47,XY,+21/46,XY, one 47,XX,+21/46,XX, one 45,X/46,XX, and one 47,XXY/46,XY) were studied using sister chromatid differential staining technique for cell kinetic evaluation: Aneuploid and normal cell lines were compared to identify changes in cellular proliferation ire vitro that could be related to cellular selective advantage and cell-line-proportion changes occurring with age. Comparison of the percentage of cells in different cell generations in 48, 72, and 96 h-cultures shows no differences between the aneuploid and normal cell lines indicating that cell-cycle kinetics is similar in these cells in vitro. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
Palavra-chave chromosomal mosaicism
cell-cycle
cell selection
Down syndrome
Turner syndrome
Klinefelter syndrome
Idioma Inglês
Data de publicação 2001-04-01
Publicado em Annales de Genetique. Paris Cedex 15: Editions Scientifiques Medicales Elsevier, v. 44, n. 2, p. 93-97, 2001.
ISSN 0003-3995 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 93-97
Fonte http://dx.doi.org/10.1016/S0003-3995(01)01070-X
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000170848900009
Endereço permanente http://repositorio.unifesp.br/handle/11600/26517

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