Early detection of heart transplant patients with increased risk of ciclosporin nephrotoxicity

Early detection of heart transplant patients with increased risk of ciclosporin nephrotoxicity

Autor Camara, NOS Google Scholar
Matos, ACC Google Scholar
Rodrigues, D. A. Google Scholar
Pereira, A. B. Google Scholar
Pacheco-Silva, A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Chronic nephrotoxic effects from ciclosporin are a common clinical complication after heart transplantation and frequently lead to progressive renal failure. There is no laboratory test to predict development of chronic renal failure in heart transplant patients. We analysed urinary retinol-binding protein (uRBP) concentration, to assess proximal tubular dysfunction, in 36 clinically stable heart transplant patients. We detected a subgroup of 13 patients who had high concentrations of uRBP, good renal function, and a high risk of developing progressive renal failure compared with patients with normal uRBP (relative risk 3.87, p=0.003).
Idioma Inglês
Data de publicação 2001-03-17
Publicado em Lancet. London: Lancet Ltd, v. 357, n. 9259, p. 856-857, 2001.
ISSN 0140-6736 (Sherpa/Romeo, fator de impacto)
Publicador Lancet Ltd
Extensão 856-857
Fonte http://dx.doi.org/10.1016/S0140-6736(00)04207-0
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000167586300016
Endereço permanente http://repositorio.unifesp.br/handle/11600/26509

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