Isolation and characterisation of genomic and cDNA clones coding for a serine-, alanine-, and proline-rich protein of Trypanosoma cruzi

Isolation and characterisation of genomic and cDNA clones coding for a serine-, alanine-, and proline-rich protein of Trypanosoma cruzi

Autor Carmo, M. S. Google Scholar
Santos, MRM Google Scholar
Cummings, L. M. Google Scholar
Araya, J. E. Google Scholar
Yamauchi, L. M. Google Scholar
Yoshida, N. Google Scholar
Mortara, R. A. Google Scholar
Silveira, J. F. da Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Univ Antofagasta
Resumo We report here the isolation and characterisation of genomic and cDNA clones encoding a Serine-, Alanine-, and Proline-rich protein (SAP) of Trypanosoma cruzi metacyclic trypomastigotes. the deduced peptides translated from these clones were characterised by a high content of residues of alanine, proline, serine, glycine, valine, and threonine distributed in several repeats: P2-4, S2-3, A(2-3), AS, SA, PA, AP, SP, PS, and TP. the repeats are partially homologous to the serine-, alanine-, and proline-containing motifs of Leishmania major and Leishmania mexicana proteophosphoglycans. Genes coding for SAP are part of a polymorphic family whose members are linked to members of gp85/ sialidase and mucin-like gene families. This is consistent with the hypothesis that this genetic organisation could be a means by which T. cruzi co-ordinates the expression of major surface proteins. (C) 2001 Australian Society for Parasitology Inc. Published by Elsevier B.V. All rights reserved.
Palavra-chave Trypanosoma cruzi
metacyclic trypomastigote
serine-, alanine-, and proline-rich protein (SAP)
surface membrane protein
multigene family
Idioma Inglês
Data de publicação 2001-03-01
Publicado em International Journal for Parasitology. Oxford: Pergamon-Elsevier B.V., v. 31, n. 3, p. 259-264, 2001.
ISSN 0020-7519 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 259-264
Fonte http://dx.doi.org/10.1016/S0020-7519(00)00170-3
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000167627700004
Endereço permanente http://repositorio.unifesp.br/handle/11600/26500

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