Altered neutrophil homeostasis in kinin B1 receptor-deficient mice

Altered neutrophil homeostasis in kinin B1 receptor-deficient mice

Autor Araujo, R. C. Google Scholar
Kettritz, R. Google Scholar
Fichtner, I Google Scholar
Paiva, ACM Google Scholar
Pesquero, J. B. Google Scholar
Bader, M. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Max Delbruck Ctr Mol Med
Resumo The kallikrein-kinin system is activated during inflammation and plays a major role in the inflammatory process. One of the main mechanisms of kinin action includes the modulation of neutrophil function employing both receptors for kinins, B1 and B2, in this report we show by the use of B1 receptor-deficient mice that neutrophil migration in inflamed tissues is dependent on kinin B1 receptors, However, there is no change in circulating leukocyte number and composition after genetic ablation of this receptor. Furthermore, apoptosis of neutrophils necessary for the resolution of persistent inflammatory processes is impaired in mice lacking the B1 receptor. We also show that this receptor is expressed on neutrophils, thus it may be directly involved in the induction of apoptosis in these cells after prolonged activation at inflamed sites. in conclusion, our data show that the kinin B1 receptor modulates migration and the life span of neutrophils at sites of inflammation and may be therefore an important drug target in the therapy of inflammatory diseases.
Palavra-chave B1 receptor
bradykinin
gene targeting
immune system
inflammation
leukocytes
Idioma Inglês
Data de publicação 2001-01-01
Publicado em Biological Chemistry. Berlin: Walter de Gruyter & Co, v. 382, n. 1, p. 91-95, 2001.
ISSN 1431-6730 (Sherpa/Romeo, fator de impacto)
Publicador Walter de Gruyter & Co
Extensão 91-95
Fonte http://dx.doi.org/10.1515/BC.2001.014
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000167243100014
Endereço permanente http://repositorio.unifesp.br/handle/11600/26466

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