Autoantibodies specificity in acute anterior uveitis according to the presence of the HLA-B27 allele

Autoantibodies specificity in acute anterior uveitis according to the presence of the HLA-B27 allele

Autor Trevisani, VFM Google Scholar
Mattos, KTF Google Scholar
Esteves, R. F. Google Scholar
Olialves, SMR Google Scholar
Andrade, LEC Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Purpose: To study HLA-B27circle plus and HLA-B27O patients with AAU with respect to the frequency and specificity of organ-specific and non-organ-specific autoantibodies. Methods: Fifty-seven consecutive patients with AAU were subjected to ophthalmologic and rheumatologic evaluation as well as to autoantibody determination: antinuclear antibodies (ANA), rheumatoid factor (RF), anticardiolipin, anti-smooth muscle, and anti-parietal cell antibodies, and immunoblot for antibodies to HeLa cells and to bovine iris extract. HLA-B27 was determined by a microlymphocytotoxicity assay. Statistical analysis employed chi-square test, Fisher's exact test, and McNemar test. Results: Thirty-four patients had the HLA-B27 allele (B27circle plus/AAU) and 23 did not (B27O/AAU). ANA, RF, anticardiolipin, and anti-parietal cell antibodies appeared in low frequency. No patient presented anti-smooth muscle antibody. Immunoblot showed a high frequency of antibodies to HeLa cell proteins in B27O/AAU patients with predominant reactivity at 46 kDa and 56kDa. in contrast, sera from B27circle plus/AAU patients reacted poorly against HeLa cell antigens. Immunoblot with bovine iris extract showed a significant frequency of antibodies in both groups, with a predominant response to antigens with an estimated mobility of 35, 52, and 54 kDa. Conclusion: Antibodies specific to iris antigens were equally frequent in both acute uveitis groups, whereas non-organ-specific autoantibodies, especially those to HeLa cell proteins, were far less frequent in B27circle plus/AAU than in B27O/AAU patients.
Palavra-chave autoantibodies
anterior uveitis
HLA-B27
Idioma Inglês
Data de publicação 2001-01-01
Publicado em Ocular Immunology and Inflammation. Lisse: Swets Zeitlinger Publishers, v. 9, n. 4, p. 231-242, 2001.
ISSN 0927-3948 (Sherpa/Romeo, fator de impacto)
Publicador Swets Zeitlinger Publishers
Extensão 231-242
Fonte http://dx.doi.org/10.1076/ocii.9.4.231.3952
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000174654800002
Endereço permanente http://repositorio.unifesp.br/handle/11600/26455

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