Pinealectomy-associated decrease in ribosomal gene activity in rats

Pinealectomy-associated decrease in ribosomal gene activity in rats

Autor Payao, SLM Google Scholar
Carvalho, C. V. de Google Scholar
Silva, E. R. da Google Scholar
Lopes, C. Google Scholar
Markus, R. P. Google Scholar
Winter, LMF Google Scholar
Smith, MDC Google Scholar
Instituição Fac Med Marilia
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo A decrease in ribosomal gene activity is an essential feature of the aging process as it was observed in Alzheimer's disease, in elderly Down's patients and in elderly healthy people. It is well known that aging is also associated with a reduction in melatonin synthesis. We studied 24 male Wistar rats cytogenetically, by using Ag-stained NOR (6 three-month-old rats underwent. pinealectomy and were studied after 20 days; 6 control rats of the same age 6 three-month-old rats underwent pinealectomy and were studied after 8 months; 6 control rats of the same age). Our results indicate that the absence of the pineal gland leads to a decrease in NOR activity. Further studies are necessary to determine if pinealectomy in rats could provide an animal model for aging.
Palavra-chave nucleolus organizer regions (NOR)
pineal gland
ribosomal genes
Idioma Inglês
Data de publicação 2001-01-01
Publicado em Biogerontology. Dordrecht: Kluwer Academic Publ, v. 2, n. 2, p. 105-108, 2001.
ISSN 1389-5729 (Sherpa/Romeo, fator de impacto)
Publicador Kluwer Academic Publ
Extensão 105-108
Fonte http://dx.doi.org/10.1023/A:1011541302289
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000169613400003
Endereço permanente http://repositorio.unifesp.br/handle/11600/26451

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