Interaction between the adrenal and the pineal gland in chronic experimental inflammation induced by BCG in mice

Interaction between the adrenal and the pineal gland in chronic experimental inflammation induced by BCG in mice

Autor Lopes, C. Google Scholar
Mariano, M. Google Scholar
Markus, R. P. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo Objective: To investigate the adrenal gland influence on diurnal rhythm of chronic inflammation induced by BCG in mice and its interaction with the pineal gland.Methods: C57B1/6 mice were injected with BCG in the footpad and maintained in a 12/12 h light-dark cycle. Air the experimental manipulations were done after 20-45 days. Paw swelling was measured every 4 h for 48 or 72 h and decomposed by Fourier transformation. Vascular permeability was evaluated by Evans Blue overflow, in mice killed at midday or midnight. 6-Sulphatoxymelatonin urine concentration was determined by radioimmunoassay in samples taken during the dark or light phase.Results: Adrenalectomy or metyrapone treatment abolished the paw swelling diurnal. rhythm, the nocturnal reduction in vascular permeability, and the nocturnal increase in 6-sulphatoximelatonin in the urine. Nocturnal administration of melatonin to adrenalectomized mice restored the paw swelling diurnal variation and the reduction of vascular permeability of the inflamed paw.Conclusion: Adrenal cortical hormones are important for the maintenance of the diurnal rhythm of chronic inflammation (paw swelling and vascular permeability), probably by promoting a nocturnal surge of melatonin, which is the hormone that modulates the diurnal variation of chronic inflammation.
Palavra-chave chronic inflammation
circadian rhythm
adrenal gland
pineal gland
Idioma Inglês
Data de publicação 2001-01-01
Publicado em Inflammation Research. Basel: Birkhauser Verlag Ag, v. 50, n. 1, p. 6-11, 2001.
ISSN 1023-3830 (Sherpa/Romeo, fator de impacto)
Publicador Birkhauser Verlag Ag
Extensão 6-11
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000166986600002
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