Liver microcirculation after selective denervation

Liver microcirculation after selective denervation

Autor Pedrosa, M. E. Google Scholar
Montero, EFS Google Scholar
Nigro, AJT Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Microcirculatory disturbances have been related to a decrease in survival after liver transplant. Because innervation is involved in liver hemodynamics regulation, we decided to evaluate microcirculatory hepatic perfusion. Thirty rats were divided into three groups: denervated (DG), hepatic microsurgical denervation; manipulated (MG), hepatic manipulation; control (CG), laparotomy. Hepatic microcirculation was assessed in the median lobe using laser Doppler flowmetry in the following moments: T-0, after laparotomy and T-1, after denervation; and in the following moments after derevation: T-2, 10 minutes, T-3, 20 minutes, T-4, 30 minutes, T-5, 1 hour, T-6, 1.5 hours, and T-7, 2 hours for DG, and in same moments for MG and CG. DG showed a decrease in hepatic perfusion for 20 minutes after denervation, different from MG and CG. After that, there was recovery in hepatic perfusion in MG and DG (Kruskal-Wallis and Friedman tests). Therefore, denervation and manipulation alter hepatic microcirculation, but denervation promotes a more severe decrease than manipulation. (C) 2001 Willey-Liss, Inc.
Idioma Inglês
Data de publicação 2001-01-01
Publicado em Microsurgery. New York: Wiley-liss, v. 21, n. 4, p. 163-165, 2001.
ISSN 0738-1085 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 163-165
Fonte http://dx.doi.org/10.1002/micr.1031
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000169363700013
Endereço permanente http://repositorio.unifesp.br/handle/11600/26440

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