Quantitative evaluation of rRNA in Alzheimer's disease

Quantitative evaluation of rRNA in Alzheimer's disease

Autor Silva, AMA da Google Scholar
Payao, SLM Google Scholar
Borsatto, B. Google Scholar
Bertolucci, PHF Google Scholar
Smith, MDC Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Fac Med Marilia
Resumo The ribosomal RNA (rRNA) genes are located in nucleolus during active transcription and are transcribed by RNA polymerase I. This group of genes is involved in transcription and translation processes which can modulate gene expression. the association between rRNA levels and aging has been reported. in the present study, Eve investigated the ratio of mature rRNA 28S and 18S in peripheral blood of 15 Alzheimer's disease (AD) patients, 15 elderly healthy controls and 15 healthy young controls. Our results showed a statistically significant decrease of the mature rRNA 28S/18S ratio in AD patients when compared with the elderly and young control groups. Thus we can suggest that there is a possible change in the transcriptional or maturation process or a preferential degradation of the 28S subunit in AD. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
Palavra-chave aging
Alzheimer's disease
rRNA
Idioma Inglês
Data de publicação 2000-12-01
Publicado em Mechanisms of Ageing and Development. Clare: Elsevier Sci Ireland Ltd, v. 120, n. 1-3, p. 57-64, 2000.
ISSN 0047-6374 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 57-64
Fonte http://dx.doi.org/10.1016/S0047-6374(00)00180-9
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000165650600005
Endereço permanente http://repositorio.unifesp.br/handle/11600/26425

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