Quantitative evaluation of rRNA in Alzheimer's disease

Quantitative evaluation of rRNA in Alzheimer's disease

Author Silva, AMA da Google Scholar
Payao, SLM Google Scholar
Borsatto, B. Google Scholar
Bertolucci, PHF Google Scholar
Smith, MDC Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Fac Med Marilia
Abstract The ribosomal RNA (rRNA) genes are located in nucleolus during active transcription and are transcribed by RNA polymerase I. This group of genes is involved in transcription and translation processes which can modulate gene expression. the association between rRNA levels and aging has been reported. in the present study, Eve investigated the ratio of mature rRNA 28S and 18S in peripheral blood of 15 Alzheimer's disease (AD) patients, 15 elderly healthy controls and 15 healthy young controls. Our results showed a statistically significant decrease of the mature rRNA 28S/18S ratio in AD patients when compared with the elderly and young control groups. Thus we can suggest that there is a possible change in the transcriptional or maturation process or a preferential degradation of the 28S subunit in AD. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
Keywords aging
Alzheimer's disease
Language English
Date 2000-12-01
Published in Mechanisms of Ageing and Development. Clare: Elsevier Sci Ireland Ltd, v. 120, n. 1-3, p. 57-64, 2000.
ISSN 0047-6374 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 57-64
Origin http://dx.doi.org/10.1016/S0047-6374(00)00180-9
Access rights Closed access
Type Article
Web of Science ID WOS:000165650600005
URI http://repositorio.unifesp.br/handle/11600/26425

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