Receptors coupling to G proteins: Is there a signal behind the sequence?

Receptors coupling to G proteins: Is there a signal behind the sequence?

Autor Horn, F. Google Scholar
van der Wenden, E. M. Google Scholar
Oliveira, Laerte Autor UNIFESP Google Scholar
IJzerman, A. P. Google Scholar
Vriend, Gerrit Google Scholar
Instituição CMBI
European Mol Biol Lab
Leiden Univ
Universidade Federal de São Paulo (UNIFESP)
Resumo Upon the binding of their ligands, G protein-coupled receptors couple to the heterotrimeric G proteins to transduce a signal. One receptor family may couple to a single G protein subtype and another family to several ones. Is there a signal in the receptor sequence that can give an indication of the G protein subtype selectivity? We used a sequence analysis method on biogenic amine and adenosine receptors and concluded that a weak signal can be detected in receptor families where specialization for coupling to a given G protein occurred during a recent divergent evolutionary process. Proteins 2000;41:448-459. (C) 2000 Wiley-Liss, Inc.
Palavra-chave receptor
GPCR
G protein selectivity
correlated mutations
sequence analysis
Idioma Inglês
Data de publicação 2000-12-01
Publicado em Proteins-structure Function and Genetics. New York: Wiley-liss, v. 41, n. 4, p. 448-459, 2000.
ISSN 0887-3585 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 448-459
Fonte http://dx.doi.org/10.1002/1097-0134(20001201)41:4<448
Direito de acesso Acesso restrito
Tipo Resenha
Web of Science WOS:000165365500003
Endereço permanente http://repositorio.unifesp.br/handle/11600/26421

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