Involvement of the opioid system in the development and expression of sensitization to the locomotor-activating effect of ethanol

Involvement of the opioid system in the development and expression of sensitization to the locomotor-activating effect of ethanol

Autor Camarini, Rosana Autor UNIFESP Google Scholar
Pires, Maria Laura Nogueira Autor UNIFESP Google Scholar
Calil, Helena Maria Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Univ Calif San Francisco
Oregon Hlth Sci Univ
Resumo Previous studies have shown that pretreatment with naloxone (Nlx), an opiate antagonist, attenuates the stimulating effect of ethanol. the purpose of the present study was to determine the influence of Nix on the development and expression of the sensitization to ethanol. Initially, effects of different doses of Nix on the response to a low dose of ethanol (2.0 g/kg) were assessed. Nix (1.0 and 3.0 mg/kg i.p.) decreased the stimulating effect of ethanol. Groups of mice were treated with saline or Nix (1.0 mg/kg i.p.) plus saline or ethanol (2.0 g/kg if) during 21 d. On day 25 of treatment all animals received an ethanol challenge (2.0 g/kg i.p.). It significantly increased the locomotor activity of mice that had received chronic ethanol (2.0 g/kg) once daily as compared to those that had received saline. Chronic administration of Nlx (1.0 mg/kg i.p.), during the same period of time, did not change the locomotor activity of the mice. However, the group concomitantly treated with Nix + ethanol did not develop sensitization to the locomotor-activating effect of ethanol. Another experiment was carried out to determine the effects of Nix on the expression of sensitization to ethanol. Acute pretreatment with Nix did not change the response of the mice that had developed sensitization to ethanol. These data show Nix's prevention of the development of ethanol-induced sensitization but not of its expression, suggesting an important role of the opioid neurotransmitter systems modulating the development of sensitization to the locomotor-activating effect of ethanol.
Palavra-chave ethanol
naloxone
sensitization
opioid systems
Idioma Inglês
Data de publicação 2000-12-01
Publicado em International Journal of Neuropsychopharmacology. New York: Cambridge Univ Press, v. 3, n. 4, p. 303-309, 2000.
ISSN 1461-1457 (Sherpa/Romeo, fator de impacto)
Publicador Cambridge Univ Press
Extensão 303-309
Fonte http://dx.doi.org/10.1017/S146114570000211X
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000166252100004
Endereço permanente http://repositorio.unifesp.br/handle/11600/26417

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