Allelic polymorphisms of human Fc gamma receptor IIa and Fc gamma receptor IIIb among distinct groups in Brazil

Allelic polymorphisms of human Fc gamma receptor IIa and Fc gamma receptor IIIb among distinct groups in Brazil

Autor Kuwano, S. T. Google Scholar
Bordin, J. O. Google Scholar
Chiba, A. K. Google Scholar
Mello, A. B. Google Scholar
Figueiredo, M. S. Google Scholar
Vieira, JPB Google Scholar
Fabron, A. Google Scholar
Kerbauy, J. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Marilia Med Fac
Resumo BACKGROUND: the Fc gamma RIIA gene is expressed in two polymorphic farms, R131 and H131, which differ by the replacement of histidine by arginine at position 131. the FCGR3B (Fc gamma RIIIB) gene exists in two allelic isoforms, known as FCGR3B1 (Fc gamma RIIIB-NA1) and FCGR3B2 (Fc gamma RIIIB-NA2), which differ in nucleotides 141, 147, 227, 277, and 349. An additional polymorphism is the SH antigen that is associated with the FCGR3B3 (Fc gamma RIIIB-SH) allele.STUDY DESIGN and METHODS: By use of a PGR with allele-specific primers, the allelic polymorphisms of Fc gamma RIIA and Fc gamma RIIIB were determined among 263 unrelated Brazilian subjects, including Amazon Indians (n = 92), blood donors (n = 85), and patients with sickle cell disease (SCD) (n = 86).RESULTS: Amazon Indians had a significantly higher frequency of the R131 allele than did blood donors and SCD patients (0.91 vs. 0.55 vs. 0.55; p<0.001). NA1 and NA2 gene frequencies were found to be 0.67 and 0.21 for Amazon Indians, 0.58 and 0.42 for blood donors, and 0.61 and 0.39 for SCD patients, respectively. the Fc<gamma>RIIIB-SH allele was absent from the Amazon Indians, but 9 (10.6%) blood donors and 10 (11.6%) SCD patients expressed this allele.CONCLUSION: Overall, the data indicate that the distribution of the Fc gamma RIIIB alleles is significantly different in Amazon Indians from the distribution in Brazilian blood donors or African Brazilian patients with SCD, but that it is similar to the distributions reported in Asian populations. Moreover, the distribution of the Fc gamma RIIA and Fc gamma RIIIB alleles among Brazilian blood donors and SCD patients is comparable to the distributions reported in whites from the United States and Europe.
Idioma Inglês
Data de publicação 2000-11-01
Publicado em Transfusion. Bethesda: Amer Assoc Blood Banks, v. 40, n. 11, p. 1388-1392, 2000.
ISSN 0041-1132 (Sherpa/Romeo, fator de impacto)
Publicador Amer Assoc Blood Banks
Extensão 1388-1392
Fonte http://dx.doi.org/10.1046/j.1537-2995.2000.40111388.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000165492600017
Endereço permanente http://repositorio.unifesp.br/handle/11600/26409

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