The plus-maze discriminative avoidance task: a new model to study memory-anxiety interactions. Effects of chlordiazepoxide and caffeine

The plus-maze discriminative avoidance task: a new model to study memory-anxiety interactions. Effects of chlordiazepoxide and caffeine

Autor Silva, R. H. Google Scholar
Frussa, R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The plus-maze discriminative avoidance paradigm is a new animal model of learning/memory that provides simultaneous information about anxiety. Mice are conditioned to choose between the two enclosed arms tin one of which light and noise are presented as aversive stimuli) while avoiding the two open arms of the apparatus. the test has the advantage of measuring, at the same time and in the same animals, learning/memory (by the percent time spent in aversive enclosed arm - PTAV) and anxiety (by the percent time spent in the open arms - PTO). the effects of chlordiazepoxide and caffeine on learning/memory and anxiety of mice tested in this paradigm were investigated. Chlordiazepoxide (5 mg/kg) significantly increased and caffeine (20 mg/kg) significantly decreased PTO during the training session, suggesting an anxiolytic and an anxiogenic effect, respectively. in the test session, chlordiazepoxide- or caffeine-treated mice presented higher PTAV, suggesting amnestic effects. Given together, chlordiazepoxide plus caffeine did not alter PTO, and the amnesic effect produced by each drug was no longer observed. It is concluded that learning/memory depends on an optimum emotional level. the pins-maze discriminative avoidance model appears to be a useful test to investigate this critical relationship between learning/memory and anxiety. (C) 2000 Elsevier Science B.V. All rights reserved.
Palavra-chave caffeine
chlordiazepoxide
behavior
avoidance-learning
anxiety
Idioma Inglês
Data de publicação 2000-10-30
Publicado em Journal of Neuroscience Methods. Amsterdam: Elsevier B.V., v. 102, n. 2, p. 117-125, 2000.
ISSN 0165-0270 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 117-125
Fonte http://dx.doi.org/10.1016/S0165-0270(00)00289-2
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000165094800004
Endereço permanente http://repositorio.unifesp.br/handle/11600/26400

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