Angiotensinogen and angiotensin converting enzyme gene polymorphisms and the risk of bipolar affective disorder in humans

Angiotensinogen and angiotensin converting enzyme gene polymorphisms and the risk of bipolar affective disorder in humans

Autor Meira-Lima, IV Google Scholar
Pereira, A. C. Google Scholar
Mota, GFA Google Scholar
Krieger, J. E. Google Scholar
Vallada, H. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo A possible participation of the renin-angiotensin system (RAS) components with mood disturbances has been suggested in both animal and pharmacological models. in this cross-sectional study, we examined the association between functional polymorphisms in the angiotensin converting enzyme (ACE) and angiotensinogen (AGI) genes in 115 bipolar affective disorder (BPAD) patients and 323 healthy control subjects. the ACE I/D variant did not show any difference in allelic frequencies and genotypic distribution between the groups. in contrast, when studying the AGT M235T polymorphism we found that the M allele was more frequently observed in BPAD patients than in controls (chi (2) = 6.766, d.f. = 1, P = 0.009). Using multivariate logistic models the strongest odds ratio resulted from a dominant genetic model (OR = 3.0; CI (95%) 1.7-5.3] Our data suggest an association between the AGT M235 genotype and increased susceptibility for BPAD in these Brazilian patients. These findings are consistent with the hypothesis that the RAS system plays a role in regulating the mood (C) 2000 Published by Elsevier Science Ireland Ltd.
Palavra-chave affective disorder
renin-angiotensin system
genetic
association study
Idioma Inglês
Data de publicação 2000-10-27
Publicado em Neuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 293, n. 2, p. 103-106, 2000.
ISSN 0304-3940 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 103-106
Fonte http://dx.doi.org/10.1016/S0304-3940(00)01512-3
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000090010400006
Endereço permanente http://repositorio.unifesp.br/handle/11600/26399

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