The effects of acute cocaine administration in paradoxical sleep-deprived rats

The effects of acute cocaine administration in paradoxical sleep-deprived rats

Autor Andersen, M. L. Google Scholar
Palma, B. D. Google Scholar
Rueda, A. D. Google Scholar
Tufik, S. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Recent studies demonstrate the action of cocaine on reward pathways, which are activated by pleasant stimuli. Cocaine's mechanism of action involves the blockade of dopamine and norepinephrine reuptake by the presynaptic terminal. Paradoxical sleep (PS) deprivation is known to induce several behavioural alterations most of which suggest the occurrence of supersensitivity of D-2 and a subsensitivity of beta(1) and beta(2) receptors. the present study sought to examine the effects of PS deprivation on the actions of cocaine on the erection and ejaculation behaviours in rats. Four different doses of cocaine (3.5, 7.0, 15.0 and 30.0 mg/kg) were acutely administered to Wistar male rats, at the end of a 4-day period of PS deprivation or at the equivalent time-point to control animals. Moreover, 15 mg/kg of cocaine were administered in animals submitted to immobilization, footshock and forced swimming. the data were analysed by the Chi-square test, and revealed that only PS-deprived animals exhibited penile erections and ejaculation behaviours, which were absent in control animals. PS deprivation increases the sexual behaviour of male rats, probably due to its action on dopaminergic systems. However, fur ther studies need to be carried out in order to clarify the mechanisms involved between PS deprivation and cocaine.
Idioma Inglês
Data de publicação 2000-10-01
Publicado em Addiction Biology. Basingstoke: Carfax Publishing, v. 5, n. 4, p. 417-420, 2000.
ISSN 1355-6215 (Sherpa/Romeo, fator de impacto)
Publicador Carfax Publishing
Extensão 417-420
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000089880800004
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