Estrogen, progestogen and tamoxifen increase synaptic density of the hippocampus of ovariectomized rats

Estrogen, progestogen and tamoxifen increase synaptic density of the hippocampus of ovariectomized rats

Autor Silva, I Google Scholar
Mello, LEAM Google Scholar
Freymuller, E. Google Scholar
Haidar, Mauro Abi Autor UNIFESP Google Scholar
Baracat, E. C. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The effects of gonadal steroids or tamoxifen over the synaptic density of the CA1 region of the hippocampus was investigated in ovariectomized (OVX) rats. Chronic oral administration of conjugated equine estrogen, conjugated equine medroxyprogesterone, a combination of both or tamoxifen was performed in ovariectomized (OVX) rats over a period of 60 days. Synaptic density of the stratum radiatum of the CA1 region was evaluated by means of electron microscopy. Significant increases in the range of 34-49% were found for treated animals as compared to OVX controls not subject to hormonal replacement. Our results confirm previously reported effects of estradiol over synaptic density in this region and reports for the first time an effect of medroxyprogesterone (alone or in combination with estrogen) and tamoxifen. Our findings support the notion that hormonal replacement therapy and tamoxifen might have beneficial effects for cognitive function. (C) 2000 Published by Elsevier Science Ireland Ltd.
Palavra-chave synaptic density
estrogen
progestogen
tamoxifen
CA1 hippocampus
stratum radiatum
Idioma Inglês
Data de publicação 2000-09-22
Publicado em Neuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 291, n. 3, p. 183-186, 2000.
ISSN 0304-3940 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 183-186
Fonte http://dx.doi.org/10.1016/S0304-3940(00)01410-5
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000089475100014
Endereço permanente http://repositorio.unifesp.br/handle/11600/26387

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