Phosphatidylserine reverses reserpine-induced amnesia

Phosphatidylserine reverses reserpine-induced amnesia

Autor Alves, CSD Google Scholar
Aldreatini, R. Google Scholar
Cunha, C. da Google Scholar
Tufik, S. Google Scholar
Vital, MABF Google Scholar
Instituição Univ Fed Parana
Universidade Federal de São Paulo (UNIFESP)
Resumo The effects of phosphatidylserine (PS) were studied in rats treated with reserpine (1 mg/kg) immediately after training in the passive avoidance task. in experiment I, phosphatidylserine (25 mg/kg) was administered 30 min before or immediately after training. Acute pre- or post-treatment with phosphatidylserine was effective in reversing the amnestic effect of reserpine in test trials performed 24 h and 1 week after training. Experiment II was performed to determine if the long-term pretreatment with phosphatidylserine (25 mg/kg) for 7 days is able to protect the rats against the amnestic effects of reserpine in this task. the data show that phosphatidylserine reverses the impairment induced by reserpine in trials performed 74 h and 1 week after training. These results indicate that the memory deficits associated with catecholamine depletion caused by reserpine can be attenuated by acute pre- or post-training or by long-term pretreatment with this phospholipid. (C) 2000 Elsevier Science B.V. All rights reserved.
Palavra-chave phosphatidylserine
reserpine
memory
passive avoidance
Idioma Inglês
Data de publicação 2000-09-15
Publicado em European Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 404, n. 1-2, p. 161-167, 2000.
ISSN 0014-2999 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 161-167
Fonte http://dx.doi.org/10.1016/S0014-2999(00)00607-5
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000089377500019
Endereço permanente http://repositorio.unifesp.br/handle/11600/26386

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