Sleep rebound in animals deprived of paradoxical sleep by the modified multiple platform method

Sleep rebound in animals deprived of paradoxical sleep by the modified multiple platform method

Autor Suchecki, D. Google Scholar
Palma, B. D. Google Scholar
Tufik, S. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The objective of the present study was to assess the sleep rebound of animals exposed to the modified multiple platform method (MMPM), in which cage-mate rats were placed onto narrow platforms (NP=6.5 cm in diameter), onto wide platforms (WP=14 cm in diameter) or onto a grid (GR). the last two groups were included as environmental controls for the deprivation method. Animals were implanted with bipolar electrodes in the cortex, hippocampus and neck muscle. Baseline sleep was recorded for 6 h, after which the animals were placed in one of the above-mentioned settings for 90 h and their sleep was again recorded. Comparison between baseline and post-GR recordings revealed no sleep differences in these animals. Placement of animals onto WP resulted in augmented sleep time (16%), time spent in PS (+99%), duration of PS episodes (+77%), sleep efficiency (+16%), and in reduced latency to PS (-84.8%). Finally, NP animals exhibited a dramatic increase in Sleep time (+34.3%), time spent in PS (+184.7%), duration of PS episodes (+106%), and in sleep efficiency (+34.4%). Moreover, sleep latency (-52.2%) and time spent in SWS (-12.2%) were reduced. Based on the results of sleep rebound, the data indicated that placement of animals onto narrow platforms in the MMPM was an effective PS deprivation method and the grid should be considered as an adequate environmental control. (C) 2000 Elsevier Science B.V. All rights reserved.
Palavra-chave PS deprivation
methodology
modified multiple platform method polysomnography
Idioma Inglês
Data de publicação 2000-09-01
Publicado em Brain Research. Amsterdam: Elsevier B.V., v. 875, n. 1-2, p. 14-22, 2000.
ISSN 0006-8993 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 14-22
Fonte http://dx.doi.org/10.1016/S0006-8993(00)02531-2
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000089199300002
Endereço permanente http://repositorio.unifesp.br/handle/11600/26371

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