Effects of the selective M1 muscarinic receptor antagonist dicyclomine on emotional memory

Effects of the selective M1 muscarinic receptor antagonist dicyclomine on emotional memory

Autor Fornari, Raquel V. Autor UNIFESP Google Scholar
Moreira, Karin M. Autor UNIFESP Google Scholar
Oliveira, Maria Gabriela M Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The nonselective muscarinic antagonist scopolamine is known to impair the acquisition of some learning tasks such as inhibitor) avoidance. There has been recent research into the effects of this drug in contextual fear conditioning and tone fear conditioning paradigms. the purpose of the present study was to assess the role of the selective M1 muscarinic antagonist dicyclomine in these paradigms and in the inhibitory avoidance test. Rats were administered different doses of dicyclomine or saline 30 min before acquisition training. the animals were tested 24 hr later, and it was observed that 16 mg/kg of dicyclomine impaired both contextual fear conditioning and inhibitor) avoidance. However, dicyclomine (up to 64 mg/kg) did not affect tone fear conditioning. These results suggest that the selective M1 muscarinic antagonist dicyclomine differentially affects aversively motivated tasks known to be dependent on hippocampal integrity (such as contextual fear conditioning and inhibitory avoidance) but does not affect similar hippocampus-independent tasks.
Idioma Inglês
Data de publicação 2000-09-01
Publicado em Learning & Memory. Plainview: Cold Spring Harbor Lab Press, v. 7, n. 5, p. 287-292, 2000.
ISSN 1072-0502 (Sherpa/Romeo, fator de impacto)
Publicador Cold Spring Harbor Lab Press
Extensão 287-292
Fonte http://dx.doi.org/10.1101/lm.34900
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000168802100007
Endereço permanente http://repositorio.unifesp.br/handle/11600/26362

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