Endocrine cells in the denervated intestine

Endocrine cells in the denervated intestine

Autor Santos, G. C. Google Scholar
Zucoloto, S. Google Scholar
Garcia, S. B. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo This study deals with the effects of myenteric denervation of the proximal jejunum on endocrine cell population of the crypt-villus unit, 5 months after treatment with benzalkonium chloride (BAC). Male Wistar albino rats weighing on average 100 g were allocated to two groups: the BAC group - the proximal jejunal serosa was treated with 2 mM BAC for 30 min, and the control group - treated with saline solution (0,9% NaCl). There was a significant reduction in neurone number in the jejunal myenteric plexus of the BAC group and the endocrine cell population (serotoninergic and argyrophilic cells) was significantly increased in this intestine segment. in conclusion, the present findings provide further evidence that the myenteric denervation induced by BAC may lead to the development of a local imbalance of the neurotransmitters, with a consequent induction of enteroendocrine cell (argyrophilic and serotoninergic cells) hyperplasia in the crypt and villus.
Palavra-chave myenteric plexus
denervation
intestine
endocrine cell
argyrophilic cell
serotoninergic cell
rat
Idioma Inglês
Data de publicação 2000-08-01
Publicado em International Journal of Experimental Pathology. Oxford: Blackwell Science Ltd, v. 81, n. 4, p. 265-270, 2000.
ISSN 0959-9673 (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Science Ltd
Extensão 265-270
Fonte http://dx.doi.org/10.1046/j.1365-2613.2000.00160.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000089405300006
Endereço permanente http://repositorio.unifesp.br/handle/11600/26354

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