Ethanol intake during lactation I. Effects on dams' metabolism and pups' body weight gain

Ethanol intake during lactation I. Effects on dams' metabolism and pups' body weight gain

Autor Oyama, L. M. Google Scholar
Couto, R. C. Google Scholar
Couto, GEC Google Scholar
Damaso, A. R. Google Scholar
Nascimento, CMO do Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Univ Amazonas
Universidade Federal de São Carlos (UFSCar)
Resumo Wistar lactating rats (8 pups per dam) had free access to either tap water (control group, C) or one of three concentrations of ethanol (E) in the drinking water: 5% (E5), 10% (E10), and 20% (E20). All animals received normal rat chow ad libitum and were killed on day 12 of lactation. Intake of both 10% and 20% ethanol solutions decreased food intake, dams' body weight, and pups' body weight gain as compared with findings in the C group. the relative weights (g/100g b.w.) of the mammary glands (MG) and of the parametrial white adipose tissue depot were decreased only in E20 as compared with findings in the C group, Protein and lipid content of these tissues were not altered in any of the ethanol groups. in comparison with the C group, the lipogenesis rate was increased in the MG (135.6%) and liver (120.2%) in E5 and the MG (58.1%) and parametrial white adipose tissue depot (147.0%) in E20. No modifications in lipogenesis rate were noted in E10. the malic enzyme activity was decreased in the MG in E10 (25.3%) and E20 (26.4%) and in the liver in E20 (45.7%). in E5, however, it was increased in the liver (23.9%). the activity of ATP - citrate lyase in the liver was decreased in E20 (56.7%), while it was increased by 37.5% in E5 and 34.2% in E10. Blood glucose concentration of dams was not affected by ethanol ingestion. However, plasma triacylglycerol concentration was higher in E10 (17.9%) and E20 (13.3%) than in the C group, and plasma protein was lower in E20 (15.7%) than in C. We concluded that alcohol intake during lactation increased the MG lipogenesis rate; although at the highest dose, this metabolic alteration was not enough to allow normal pups' growth. However, the low dose of ethanol (5%), despite having altered dams' metabolism, did not affect pups' body weight gain. 8 2000 Elsevier Science Inc. All rights reserved.
Palavra-chave alcohol
lactation
mammary gland
liver
lipogenesis
rat
ATP-citrate lyase
malic enzyme
Idioma Inglês
Data de publicação 2000-07-01
Publicado em Alcohol. Oxford: Pergamon-Elsevier B.V., v. 21, n. 3, p. 195-200, 2000.
ISSN 0741-8329 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 195-200
Fonte http://dx.doi.org/10.1016/S0741-8329(00)00073-2
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000165348900001
Endereço permanente http://repositorio.unifesp.br/handle/11600/26337

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