Pituitary-adrenal axis and behavioural responses of maternally deprived juvenile rats to the open field

Pituitary-adrenal axis and behavioural responses of maternally deprived juvenile rats to the open field

Autor Suchecki, D. Google Scholar
Palma, B. D. Google Scholar
Tufik, S. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Adult rats submitted to maternal deprivation (DEP) on post-natal day (pnd) 11 show smaller corticosterone (CORT) response to a saline injection than non-deprived (NDEP) rats, mainly at 30 days of age. in the present study we sought to investigate the pituitary-adrenal axis response of 30-day-old DEP rats to a 5-min open-field session, with lights and sound on. Hormone levels were assessed immediately or 20 min after the end of the stress, and were compared to basal levels. the immediate ACTH response of DEP females was the highest; this difference was no longer observed at 20 min, but hormone levels were still higher than basal. Both males and females showed an augmented CORT secretion immediately after the open field session, although only the response of NDEP females was higher than that of male counterparts. Moreover, DEP females showed a lower CORT response than their NDEP counterparts immediately after the stress. the CORT stress response remained equally elevated in males and females at the 20-min time point. Finally, DEP animals, regardless of the gender, ambulated more in the centre of the open field and displayed less grooming behaviour than NDEP pups, suggesting that DEP rats are less emotional than NDEP animals. (C) 2000 Elsevier Science B.V. All rights reserved.
Palavra-chave maternal deprivation
pituitary-adrenal axis
open-field behaviours
stress
gender differences
juvenile rats
Idioma Inglês
Data de publicação 2000-06-15
Publicado em Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 111, n. 1-2, p. 99-106, 2000.
ISSN 0166-4328 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 99-106
Fonte http://dx.doi.org/10.1016/S0166-4328(00)00148-0
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000087631800010
Endereço permanente http://repositorio.unifesp.br/handle/11600/26326

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