Correlation between clinical and histological analyses in retroocular connective tissues and extraocular muscles from patients with Graves' ophthalmopathy

Correlation between clinical and histological analyses in retroocular connective tissues and extraocular muscles from patients with Graves' ophthalmopathy

Autor Matos, K. Google Scholar
Nose, V Google Scholar
Manso, P. G. Google Scholar
Furlane, R. Google Scholar
Marback, E. Google Scholar
Nakanami, C. Google Scholar
Nakanami, D. Google Scholar
Pares, L. Google Scholar
Stamato, F. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Twenty-two patients with Graves' ophthalmopathy underwent biopsy, and two patients had both eyes biopsied. the samples for the control group (n = 4) were obtained during routine non-thyroid-related corrective strabismus surgery. Ophthalmological evaluation with clinical activity score (CAS), endocrinological evaluation, and ultrasound were used in our study. Correlation between clinical and histological analyses in connective tissues and extraocular muscles from patients with Graves' ophthalmopathy was done. the echography results disclosed an enlargement in all extraocular recti muscles with the exception of one patient. Periodic acid-Schiff and Giemsa stains revealed a moderate number of mast cells in the endomysial connective tissue, none of which displayed significant degranulation. There were no signs of muscle cell damage. Fifteen of the biopsies showed weak cellular reactions with only scattered inflammatory cells. Furthermore, the inflammatory process may be localized and not equally distributed throughout the muscle. Thus, the biopsies might not be representative for the whole muscle. Statistical significance analysis was found when sex and CAS were compared (p = 0.001683) using the Fisher test.In conclusion, our investigation indicates a pleomorphic pattern of histologic findings in connective tissue and extraocular muscles in Graves' ophthalmopathy.
Palavra-chave Graves' ophthalmopathy
extraocular muscles
connective tissue
histopathology
Idioma Inglês
Data de publicação 2000-06-01
Publicado em Endocrine Pathology. Totowa: Humana Press Inc, v. 11, n. 2, p. 185-194, 2000.
ISSN 1046-3976 (Sherpa/Romeo, fator de impacto)
Publicador Humana Press Inc
Extensão 185-194
Fonte http://dx.doi.org/10.1385/EP:11:2:185
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000088396400009
Endereço permanente http://repositorio.unifesp.br/handle/11600/26325

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta