Production of IFN-gamma is impaired in patients with paracoccidioidomycosis during active disease and is restored after clinical remission

Production of IFN-gamma is impaired in patients with paracoccidioidomycosis during active disease and is restored after clinical remission

Autor Karhawi, Abdon Salam Khaled Autor UNIFESP Google Scholar
Colombo, Arnaldo Lopes Autor UNIFESP Google Scholar
Salomão, Reinaldo Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Cellular immunity is usually suppressed during paracoccidioidomycosis (PCM) and is restored after treatment. in this study we evaluated the induction of a type 1 (interferon gamma (IFN-gamma)), a type 2 (interleukin (IL)-10) and a primarily macrophage derived cytokine (tumor necrosis factor (TNF)-alpha) in peripheral blood mononuclear cells (PBMC) from patients with PCM. Eight male patients with active PCM, nine male patients with clinical remission of the disease and 10 healthy control subjects were enrolled in the study. Cytokines were induced with non-specific stimuli - phytohaemagglutin (PHA) (induces IL-10 and IFN-gamma), Lipopolysaccharide (induces TNF-alpha) - and Paracoccidioides brasiliensis antigen (PbAg) (induces IL-10, IFN-gamma and TNF-alpha). Induction of IFN-gamma with PHA differed among the three groups (P < 0.01; Kruskal-Wallis test) and with PbAg was lower in patients with active disease compared to those in clinical remission (P = 0.05; Mann-Whitney). Induction of IL-10 and of TNF-alpha was similar in the three groups. the suppressed production of IFN-gamma in patients with active disease may underscore the cellular immune deficiency seen in these patients.
Palavra-chave IFN-gamma
IL-10
paracoccidioidomycosis
tumour necrosis factor-alpha
Idioma Inglês
Data de publicação 2000-06-01
Publicado em Medical Mycology. Oxford: B I O S Scientific Publishers Ltd, v. 38, n. 3, p. 225-229, 2000.
ISSN 1369-3786 (Sherpa/Romeo, fator de impacto)
Publicador B I O S Scientific Publishers Ltd
Extensão 225-229
Fonte http://dx.doi.org/10.1080/mmy.38.3.225.229
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000087916900007
Endereço permanente http://repositorio.unifesp.br/handle/11600/26323

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