Coinfection of fibroblasts with Coxiella brunetti and Toxoplasma gondii: to each their own

Coinfection of fibroblasts with Coxiella brunetti and Toxoplasma gondii: to each their own

Autor Sinai, A. P. Google Scholar
Paul, S. Google Scholar
Rabinovitch, M. Google Scholar
Kaplan, G. Google Scholar
Joiner, K. A. Google Scholar
Instituição Yale Univ
Rockefeller Univ
Univ Kentucky
New York Hosp
Universidade Federal de São Paulo (UNIFESP)
Resumo Intracellular pathogens have evolved distinct strategies to subvert host cell defenses. Ar diametrically opposed ends of the spectrum with regard to the host endosomal/lysosomal defenses are the obligate intracellular protozoan Toxoplasma gondii and the bacterium Coxiella burnetti. While the intracellular replication of T. gondii requires complete avoidance of the host endocytic cascade, C. burnetti actively subverts it. This results in these organisms establishing and growing in very different vacuolar compartments. in this study we examined the potential interaction between these distinct compartments following coinfection of mammalian fibroblasts. When present: within the same cell, these organisms exhibit minimal interaction with each other. Colocalization of T. gondii and C. burnetti within the same vacuole occurs at a low frequency in doubly infected cells. in such instances only one of the organisms appears to be replication competent, emphasizing the different requirements for survival and/or intracellular growth. the potential basis for both the lack of interaction between these distinct pathogen-containing compartments, and the mechanisms to address their low frequency of colocalization are discussed in the context of our understanding of the biology of the organisms and membrane traffic in eukaryotic cells. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
Assunto Toxoplasma gondii
Coxiella burnetti
Idioma Inglês
Data 2000-06-01
Publicado em Microbes and Infection. Paris Cedex 15: Editions Scientifiques Medicales Elsevier, v. 2, n. 7, p. 727-736, 2000.
ISSN 1286-4579 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 727-736
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000088660400001

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