Discrimination between patients with acquired toxoplasmosis and congenital toxoplasmosis on the basis of the immune response to parasite antigens

Discrimination between patients with acquired toxoplasmosis and congenital toxoplasmosis on the basis of the immune response to parasite antigens

Autor Yamamoto, J. H. Google Scholar
Vallochi, A. L. Google Scholar
Silveira, Claudio Alberto Magalhaes Autor UNIFESP Google Scholar
Kalil, J. Google Scholar
Nussenblatt, R. B. Google Scholar
Cunha-Neto, E. Google Scholar
Gazzinelli, R. T. Google Scholar
Belfort, Rubens Junior Autor UNIFESP Google Scholar
Rizzo, L. V. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Fundacao EJ Zerbini
Universidade Federal de Minas Gerais (UFMG)
Fundacao Osvaldo Cruz
NEI
Resumo Many persons infected with Toxoplasma gondii develop ocular lesions, Immunologic parameters in the response to I gondii were evaluated in infected persons with and without ocular lesions and in noninfected controls. Subjects were divided into groups on the basis of presence of serum antibodies to I: gondii, presence of ocular lesions, and clinical history. Production of interleukin-2 and interferon-gamma by peripheral blood mononuclear cells from patients with probable congenital toxoplasmosis was decreased, compared with that in persons with presumed acquired infection. Cell proliferation and delayed-type skin reaction induced by soluble toxoplasma tachyzoite antigen followed the same pattern. Asymptomatic persons showed high levels of interleukin-12 and interferon-gamma, whereas persons with ocular lesions had high interleukin-1 and tumor necrosis factor-alpha responses toward soluble toxoplasma tachyzoite antigen. These data suggest that patients with ocular disease due to congenital infection show tolerance toward the parasite. Furthermore, susceptibility to ocular lesions after acquired toxoplasmosis is associated with high levels of interleukin-1 and tumor necrosis factor-alpha, whereas resistance is associated with high levels of interleukin-12 and interferon-gamma.
Idioma Inglês
Data de publicação 2000-06-01
Publicado em Journal of Infectious Diseases. Chicago: Univ Chicago Press, v. 181, n. 6, p. 2018-2022, 2000.
ISSN 0022-1899 (Sherpa/Romeo, fator de impacto)
Publicador Univ Chicago Press
Extensão 2018-2022
Fonte http://dx.doi.org/10.1086/315494
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000087923900020
Endereço permanente http://repositorio.unifesp.br/handle/11600/26315

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