Antidepressants versus placebo for the treatment of bulimia nervosa: a systematic review

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dc.contributor.author Bacaltchuk, Josué [UNIFESP]
dc.contributor.author Hay, P.
dc.contributor.author Mari, J. J.
dc.date.accessioned 2016-01-24T12:31:03Z
dc.date.available 2016-01-24T12:31:03Z
dc.date.issued 2000-04-01
dc.identifier http://dx.doi.org/10.1080/j.1440-1614.2000.00709.x
dc.identifier.citation Australian and New Zealand Journal of Psychiatry. Carlton: Blackwell Science Asia, v. 34, n. 2, p. 310-317, 2000.
dc.identifier.issn 0004-8674
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/26288
dc.description.abstract Objective: the objective of this study was to valuate the effectiveness, tolerability and acceptability of various classes of antidepressants compared with placebo in the treatment of bulimia nervosa.Method: A meta-analysis including 16 randomised controlled trials and 1300 bulimic patients was performed. Dichotomous outcomes were analysed by calculating relative risks, and continuous outcomes by calculating effect sizes. Methodological quality, heterogeneity in the results and selective publication were assessed.Results: Short-term remission in bulimic symptoms was statistically more likely on antidepressants than placebo (Relative Risk = 0.88, 95% CI = 0.83-0.94, p < 0.0001). Drop-out rates were high but no statistical difference was found between treatment groups (34.6% and 31.4% for drug and placebo; RR = 1.03, 95% CI = 0.80-1.32, p = 0.8). No difference in efficacy could be demonstrated among different classes of antidepressants.Conclusions: the use of a single antidepressant agent was clinically effective for the treatment of bulimia nervosa when compared with placebo, with an overall greater remission rate and a higher rate of drop-outs. No differential effect regarding efficacy and tolerability among the various classes of antidepressants could be demonstrated. en
dc.format.extent 310-317
dc.language.iso eng
dc.publisher Blackwell Science Asia
dc.relation.ispartof Australian and New Zealand Journal of Psychiatry
dc.rights Acesso restrito
dc.subject antidepressants en
dc.subject bulimia nervosa en
dc.subject meta-analysis en
dc.subject systematic review en
dc.title Antidepressants versus placebo for the treatment of bulimia nervosa: a systematic review en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Adelaide
dc.description.affiliation Universidade Federal de São Paulo, Paulista Sch Med, São Paulo, Brazil
dc.description.affiliation Univ Adelaide, Adelaide, SA, Australia
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Paulista Sch Med, São Paulo, Brazil
dc.identifier.doi 10.1080/j.1440-1614.2000.00709.x
dc.description.source Web of Science
dc.identifier.wos WOS:000086315800016



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