Acute Trypanosoma cruzi infection is associated with anemia, thrombocytopenia, leukopenia, and bone marrow hypoplasia: reversal by nifurtimox treatment

Acute Trypanosoma cruzi infection is associated with anemia, thrombocytopenia, leukopenia, and bone marrow hypoplasia: reversal by nifurtimox treatment

Autor Marcondes, MCG Google Scholar
Borelli, P. Google Scholar
Yoshida, N. Google Scholar
Russo, M. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo In the present work we show that acute infect-ion of C3H mice with the CL strain of Trypanosoma cruzi is characterized by an exponential growth of parasites and high mortality accompanied by anemia, thrombocytopenia, leukopenia, and bone marrow hypoplasia. Administration of nifurtimox, a trypanocydal drug currently in clinical use at different days postinfection, modulates parasitemia and prevents mortality. More importantly, none of blood and bone marrow alterations were observed in nifurtimox-treated animals when treatment was initiated early in infection, one or seven days postinoculation. the bone marrow alterations were characterized by a decrease in the total number cells as well in the number of megakaryoblasts and erythroblasts. Transfer experiments of bone marrow cells from infected mice to noninfected lethally irradiated recipients revealed a poor marrow-repopulating activity. the colony forming units-spleen assay confirmed the depression of committed clonal progenitors cells and revealed a decreased number of granulocyte/macrophage, megacariocyte and erythrocyte colonies, in summary, this is the first report showing that acute T. cruzi infection results in profound alterations of the hematopoietic system and that these alterations can be prevented by nifurtimox treatment. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
Palavra-chave Trypanosoma cruzi
bone marrow suppression
anemia
thrombocytopenia
Nifurtimo
Idioma Inglês
Data de publicação 2000-04-01
Publicado em Microbes and Infection. Paris Cedex 15: Editions Scientifiques Medicales Elsevier, v. 2, n. 4, p. 347-352, 2000.
ISSN 1286-4579 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 347-352
Fonte http://dx.doi.org/10.1016/S1286-4579(00)00333-6
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000086810400002
Endereço permanente http://repositorio.unifesp.br/handle/11600/26286

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