Ethnopharmacology, phytochemistry and pharmacology: a successful combination in the study of Croton cajucara

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dc.contributor.author Maciel, MAM
dc.contributor.author Pinto, A. C.
dc.contributor.author Arruda, A. C.
dc.contributor.author Pamplona, SGSR
dc.contributor.author Vanderlinde, F. A.
dc.contributor.author Lapa, A. J.
dc.contributor.author Echevarria, A.
dc.contributor.author Grynberg, N. F.
dc.contributor.author Colus, IMS
dc.contributor.author Farias, RAF
dc.contributor.author Costa, AML
dc.contributor.author Rao, VSN
dc.date.accessioned 2016-01-24T12:31:03Z
dc.date.available 2016-01-24T12:31:03Z
dc.date.issued 2000-04-01
dc.identifier http://dx.doi.org/10.1016/S0378-8741(99)00159-2
dc.identifier.citation Journal of Ethnopharmacology. Clare: Elsevier B.V., v. 70, n. 1, p. 41-55, 2000.
dc.identifier.issn 0378-8741
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/26283
dc.description.abstract Phytochemical and pharmacological studies of Croton cajucara were oriented by traditional medicine. the stem bark of the mature plant is a rich source of clerodane-type diterpenes: trans-dehydrocrotonin (DCTN), trans-crotonin (CTN), cis-cajucarin B, cajucarin A, cajucarinolide and two novel clerodanes, trans-cajucarin B and sacacarin. in young (18-month-old) plants, the triterpene acetyl aleuritolic acid (AAA) was the major stem bark component and in these the diterpene DCTN was not present. the highest concentration of DCTN (1.4% of dry bark) was detected in 4-6 year-old plants, while 3-year-old plants contained only 0.26% of this diterpene. Three steroids (p-sitosterol, stigmasterol and sitosterol-3-O-beta-glucoside), two flavonoids (kaempferol 3,4',7-trimethyl ether and 3,7-dimethyl ether) and one diterpene (cajucarinolide) were isolated from the leaves of this Croton. the main pharmacological activity was correlated with DCTN. This clerodane produced anti-inflammatory and antinociceptive effects and a significant hypoglycemia in alloxan-induced diabetic rats. the compound also reduced the index of gastric lesions induced by restraint-in-cold. Dose-related DCTN and CTN inhibited in vivo the basal acid secretion in pylorus-ligature rats and oxyntic glands isolated from rabbit gastric mucosa, DCTN, CTN or AAA decreased in vitro uptake basal acid secretion induced by histamine and measured with the C-14-aminopyrine uptake method. Uniquely DCTN inhibited C-14-AP uptake induced by bethanechol. the terpenoids, DCTN and AAA, and the chloroform extract of 6-month-old plants reduced gastrointestinal transit in mice. the effects of DCTN and CTN on the survival of mice bearing Sarcoma 180 and Ehrlich carcinoma ascitic tumors, on the proliferation of cultured cells and TNF alpha were determined. DCTN was also evaluated for a possible antioestrogenic activity using the immature rat as a model system for bioassay of oestrogen and for an anti-implantation effect in regularly cycling rats. the biological experiments, using the plant extracts and the terpenoids DCTN, CTN and AAA, are herein discussed. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved. en
dc.format.extent 41-55
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Journal of Ethnopharmacology
dc.rights Acesso restrito
dc.subject Croton cajucara en
dc.subject clerodane en
dc.subject trans-dehydrocrotonin en
dc.subject trans-crotonin en
dc.subject acetyl aleuritolic acid en
dc.subject pharmacological properties en
dc.title Ethnopharmacology, phytochemistry and pharmacology: a successful combination in the study of Croton cajucara en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institution Universidade Federal do Pará (UFPA)
dc.contributor.institution Univ Fed Rural Rio de Janeiro
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade Estadual de Londrina (UEL)
dc.contributor.institution Univ Fed Ceara
dc.description.affiliation Univ Fed Rio de Janeiro, Inst Quim, BR-21945970 Rio de Janeiro, Brazil
dc.description.affiliation UFPA, CCEN, Dept Quim, Belem, Para, Brazil
dc.description.affiliation Univ Fed Rural Rio de Janeiro, IB, Dept Ciencias Fisiol, Rio de Janeiro, Brazil
dc.description.affiliation Universidade Federal de São Paulo, EPM, Dept Farmacol, Setor Prod Nat, São Paulo, Brazil
dc.description.affiliation Univ Fed Rural Rio de Janeiro, Dept Quim, Rio de Janeiro, Brazil
dc.description.affiliation Univ Estadual Londrina, CCB, Dept Biol Geral, Londrina, PR, Brazil
dc.description.affiliation Univ Fed Ceara, Dept Fisiol & Farmacol, Fortaleza, Ceara, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, EPM, Dept Farmacol, Setor Prod Nat, São Paulo, Brazil
dc.identifier.doi 10.1016/S0378-8741(99)00159-2
dc.description.source Web of Science
dc.identifier.wos WOS:000086154900006



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