Ethnopharmacology, phytochemistry and pharmacology: a successful combination in the study of Croton cajucara

Ethnopharmacology, phytochemistry and pharmacology: a successful combination in the study of Croton cajucara

Autor Maciel, MAM Google Scholar
Pinto, A. C. Google Scholar
Arruda, A. C. Google Scholar
Pamplona, SGSR Google Scholar
Vanderlinde, F. A. Google Scholar
Lapa, A. J. Google Scholar
Echevarria, A. Google Scholar
Grynberg, N. F. Google Scholar
Colus, IMS Google Scholar
Farias, RAF Google Scholar
Costa, AML Google Scholar
Rao, VSN Google Scholar
Instituição Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal do Pará (UFPA)
Univ Fed Rural Rio de Janeiro
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Londrina (UEL)
Univ Fed Ceara
Resumo Phytochemical and pharmacological studies of Croton cajucara were oriented by traditional medicine. the stem bark of the mature plant is a rich source of clerodane-type diterpenes: trans-dehydrocrotonin (DCTN), trans-crotonin (CTN), cis-cajucarin B, cajucarin A, cajucarinolide and two novel clerodanes, trans-cajucarin B and sacacarin. in young (18-month-old) plants, the triterpene acetyl aleuritolic acid (AAA) was the major stem bark component and in these the diterpene DCTN was not present. the highest concentration of DCTN (1.4% of dry bark) was detected in 4-6 year-old plants, while 3-year-old plants contained only 0.26% of this diterpene. Three steroids (p-sitosterol, stigmasterol and sitosterol-3-O-beta-glucoside), two flavonoids (kaempferol 3,4',7-trimethyl ether and 3,7-dimethyl ether) and one diterpene (cajucarinolide) were isolated from the leaves of this Croton. the main pharmacological activity was correlated with DCTN. This clerodane produced anti-inflammatory and antinociceptive effects and a significant hypoglycemia in alloxan-induced diabetic rats. the compound also reduced the index of gastric lesions induced by restraint-in-cold. Dose-related DCTN and CTN inhibited in vivo the basal acid secretion in pylorus-ligature rats and oxyntic glands isolated from rabbit gastric mucosa, DCTN, CTN or AAA decreased in vitro uptake basal acid secretion induced by histamine and measured with the C-14-aminopyrine uptake method. Uniquely DCTN inhibited C-14-AP uptake induced by bethanechol. the terpenoids, DCTN and AAA, and the chloroform extract of 6-month-old plants reduced gastrointestinal transit in mice. the effects of DCTN and CTN on the survival of mice bearing Sarcoma 180 and Ehrlich carcinoma ascitic tumors, on the proliferation of cultured cells and TNF alpha were determined. DCTN was also evaluated for a possible antioestrogenic activity using the immature rat as a model system for bioassay of oestrogen and for an anti-implantation effect in regularly cycling rats. the biological experiments, using the plant extracts and the terpenoids DCTN, CTN and AAA, are herein discussed. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
Palavra-chave Croton cajucara
clerodane
trans-dehydrocrotonin
trans-crotonin
acetyl aleuritolic acid
pharmacological properties
Idioma Inglês
Data de publicação 2000-04-01
Publicado em Journal of Ethnopharmacology. Clare: Elsevier B.V., v. 70, n. 1, p. 41-55, 2000.
ISSN 0378-8741 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 41-55
Fonte http://dx.doi.org/10.1016/S0378-8741(99)00159-2
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000086154900006
Endereço permanente http://repositorio.unifesp.br/handle/11600/26283

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