Epileptogenesis in immature rats following recurrent status epilepticus

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dc.contributor.author Santos, N. F. dos
dc.contributor.author Arida, R. M.
dc.contributor.author Trindade, E. M.
dc.contributor.author Priel, M. R.
dc.contributor.author Cavalheiro, E. A.
dc.date.accessioned 2016-01-24T12:31:03Z
dc.date.available 2016-01-24T12:31:03Z
dc.date.issued 2000-04-01
dc.identifier http://dx.doi.org/10.1016/S0165-0173(99)00089-2
dc.identifier.citation Brain Research Reviews. Amsterdam: Elsevier B.V., v. 32, n. 1, p. 269-276, 2000.
dc.identifier.issn 0165-0173
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/26281
dc.description.abstract Strong evidences link; status epilepticus (SE) in childhood with the later development of epilepsy. Pilocarpine-induced SE in developing rats leads to late appearance of spontaneous epileptic seizures only when SE is induced after the 18th day of life. We examined the possibility that 3 consecutive episodes of pilocarpine-induced SE on postnatal days 7, 8 and 9 could induce behavioral, electrographic and histological epileptic changes in adult life. the animals also underwent behavioral tests (inhibitory step-down avoidance, skinner box, rota-rod, open field and elevated plus-maze). EEG recordings made at the age of 30, 60 and 90 days showed the occurrence of several episodes of spikes and/or polyspikes appearing simultaneously in hippocampus and cortex. Only three isolated spontaneous seizures were observed during the whole period of observation (120 days). the long-term effects of three consecutive episodes of SE include increased spontaneous exploratory activity, learning impairment, and reduced anxiety when tested on P60. Our findings provide evidence for EEG changes and cognitive deficits in adult life following recurrent SE on postnatal days 7-9. (C) 2000 Elsevier Science B.V. All rights reserved. en
dc.format.extent 269-276
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Brain Research Reviews
dc.rights Acesso restrito
dc.subject immature brain en
dc.subject pilocarpine en
dc.subject learning en
dc.subject memory en
dc.subject repeated status epilepticus en
dc.subject epileptogenesis en
dc.title Epileptogenesis in immature rats following recurrent status epilepticus en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.identifier.doi 10.1016/S0165-0173(99)00089-2
dc.description.source Web of Science
dc.identifier.wos WOS:000087131200033


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