Effect of estrogen-progestogen hormonal replacement therapy on periurethral and bladder vessels

Effect of estrogen-progestogen hormonal replacement therapy on periurethral and bladder vessels

Autor Endo, R. M. Google Scholar
Girao, MJBC Google Scholar
Sartori, MGF Google Scholar
Simoes, M. J. Google Scholar
Baracat, E. C. Google Scholar
Lima, G. R. de Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo This study assessed the effect of hormone replacement therapy using estrogens and/or progestogens on the number of vessels in the proximal and distal urethra, vesicourethral junction and bladder of castrated adult female rats. Forty-five virgin adult rats (Rattus norvegicus albinus) castrated for at least 30 days were used. They were assigned to five groups; group I (control) received no medication; the others received via the subcutaneous route, respectively, 17-beta-estradiol (group II), medroxyprogesterone acetate (group III), a maize oil and benzyl acid solution - placebo (group IV) and 17-beta-estradiol combined with medroxyprogesterone acetate (group V), for a minimum of 28 days. Increased vascularization throughout the urinary tract, except in the distal urethra, was found following estrogen replacement alone. in the group that received combined estrogens and progestogens, no increase was found. It was concluded that estrogen replacement in castrated rats significantly increased the number of vessels in the lower urinary tract.
Palavra-chave hypoestrogenism
stress urinary incontinence
urethral vessels
Idioma Inglês
Data de publicação 2000-04-01
Publicado em International Urogynecology Journal and Pelvic Floor Dysfunction. Godalming: Springer-verlag London Ltd, v. 11, n. 2, p. 120-123, 2000.
ISSN 0937-3462 (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 120-123
Fonte http://dx.doi.org/10.1007/PL00004024
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000086917300010
Endereço permanente http://repositorio.unifesp.br/handle/11600/26278

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