Effects of short-term glucocorticoid deprivation on growth hormone (GH) response to GH-releasing peptide-6: Studies in normal men and in patients with adrenal insufficiency

Effects of short-term glucocorticoid deprivation on growth hormone (GH) response to GH-releasing peptide-6: Studies in normal men and in patients with adrenal insufficiency

Autor Pinto, Ana Claudia de Assis Rocha Autor UNIFESP Google Scholar
Dias-da-Silva, Magnus Régios Autor UNIFESP Google Scholar
Martins, Manoel R. Autor UNIFESP Google Scholar
Brunner, Elisa Autor UNIFESP Google Scholar
Lengyel, Ana Maria Judith Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo There are no data in the literature about the effects of glucocorticoid deprivation on GH-releasing peptide-g (GHRP-6)-induced GH release. the aims of this study were to evaluate GH responsiveness to GHRP-6 1) after metyrapone administration in normal men, and 2) in patients with chronic hypocortisolism after glucocorticoid withdrawal for 72 h. in normal subjects, metyrapone ingestion did not alter significantly GH responsiveness to GHRP-6 [n = 8; peak, 39.3 +/- 7.1 mu g/L; area under the curve (AUC), 1958.8 +/- 445.7 mu g/min.L; mean +/- SE] compared to placebo (n = 8; peak, 21.9 +/- 4.5; AUG, 1131.0 +/- 229.6). in patients with chronic hypocortisolism (n = 8), GH responses to GHRP-6 were similar both during replacement therapy (peak, 11.8 +/- 3.9; AUG, 563.2 +/- 208.7) and after withdrawal of prednisone (peak, 14.4 +/-: 4.5; AUG, 695.6 +/- 272.9) and did not differ from those in controls. interestingly after glucocorticoid withdrawal, GH responsiveness to GHRP-6 in patients with chronic hypocortisolism was significantly lower than that in normal subjects pretreated with metyrapone. Our data suggest that short term glucocorticoid deprivation does not have a major impact on GHRP-6-dependent GH-releasing mechanisms. However, in long standing hypocortisolism, subtle changes in GHRP-6 secretory pathways may be present.
Idioma Inglês
Data de publicação 2000-04-01
Publicado em Journal of Clinical Endocrinology & Metabolism. Chevy Chase: Endocrine Soc, v. 85, n. 4, p. 1540-1544, 2000.
ISSN 0021-972X (Sherpa/Romeo, fator de impacto)
Publicador Endocrine Soc
Extensão 1540-1544
Fonte http://dx.doi.org/10.1210/jcem.85.4.6536
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000088387200030
Endereço permanente http://repositorio.unifesp.br/handle/11600/26277

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta