Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis collected from five centers in Brazil, 1997-98

Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis collected from five centers in Brazil, 1997-98

Autor Critchley, I. A. Google Scholar
Thornsberry, C. Google Scholar
Piazza, G. Google Scholar
Jones, M. Google Scholar
Hickey, M. L. Google Scholar
Barth, A. L. Google Scholar
Mendes, C. Google Scholar
Rossi, F. F. Google Scholar
Sader, Helio Silva Autor UNIFESP Google Scholar
Teixeira, L. M. Google Scholar
Sahm, D. F. Google Scholar
Instituição MRL
MRL Pharmaceut Serv
Hosp Clin Porto Alegre
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio de Janeiro (UFRJ)
Resumo Objective To assess the susceptibility of the : key respiratory pathogens Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis to antimicrobial agents used to treat respiratory tract infections.Methods isolates were collected from five centers in Brazil during 1997-98, and susceptibility testing was conducted at a central laboratory according to National Committee for Clinical Laboratory Standards criteria.Results of the 359 Streptococcus pneumoniae isolates tested, 77% were susceptible, 19% were intermediate and 4% were resistant to penicillin. the susceptibility of S. pneumoniae to other beta-lactams and macrolides was greater than 90%, but cotrimoxazole was active against only 48% of the: isolates, the prevalence of susceptible isolates was 100.0% for vancomycin and 99.7% for levofloxacin. beta-Lactram, macrolide, and cotrimoxazole activities were negatively associated with penicillin resistance. of the 219 isolates of Haemophilus influenzae tested, 11% produced beta-lactamase and 11% were not susceptible to ampicillin. Nearly all H. influenzae isolates were susceptible to all other drugs, except cotrimoxazole (47% susceptibility). of the 52 Moraxella catarrhalis isolates, 98% produced beta-lactamase, and the MIC of all drugs was less than or equal to 4 mg/L, with the exception of amyicillin, where the: MIC90 was > 8 mg/L.Conclusions When these data are compared with previous reports, our findings suggest that the prevalence of pneumococci that are resistant to agents such as penicillin and cotrimoxazole may be increasing in Brazil, which highlights the need to continue surveillance programs.
Palavra-chave Streptococcus pneumoniae
antibiotic resistance
surveillance
Idioma Inglês
Data de publicação 2000-04-01
Publicado em Clinical Microbiology and Infection. Oxford: Blackwell Science Ltd, v. 6, n. 4, p. 178-184, 2000.
ISSN 1198-743X (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Science Ltd
Extensão 178-184
Fonte http://dx.doi.org/10.1046/j.1469-0691.2000.00063.x
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000086961300002
Endereço permanente http://repositorio.unifesp.br/handle/11600/26275

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