Activity and spectrum of 22 antimicrobial agents tested against urinary tract infection pathogens in hospitalized patients in Latin America: report from the second year of the SENTRY Antimicrobial Surveillance Program (1998)

Activity and spectrum of 22 antimicrobial agents tested against urinary tract infection pathogens in hospitalized patients in Latin America: report from the second year of the SENTRY Antimicrobial Surveillance Program (1998)

Autor Gales, Ana C. Autor UNIFESP Google Scholar
Jones, R. N. Google Scholar
Gordon, K. A. Google Scholar
Sader, Helio S. Autor UNIFESP Google Scholar
Wilke, W. W. Google Scholar
Beach, M. L. Google Scholar
Pfaller, M. A. Google Scholar
Doern, G. V. Google Scholar
SENTRY Study Grp Latin Amer Google Scholar
Instituição Univ Iowa
Universidade Federal de São Paulo (UNIFESP)
Resumo The potency and spectrum of various antimicrobial agents tested against 434 bacterial isolates causing urinary tract infection (UTI) in hospitalized patients in Latin America were evaluated. the genotypes of the extended-spectrum beta-lactamase-producing and selected multi-resistant isolates were also evaluated by molecular typing techniques. Escherichia coli (60.4%) was the most common aetiological agent causing UTI, followed by Klebsiella spp. (11.2%) and Pseudomonas aeruginosa (8.3%). in contrast, Enterococcus spp. isolates caused only 2.3% of UTIs. Fewer than 50% of E. coli isolates were susceptible to broad-spectrum penicillins. the resistance rates to ciprofloxacin and the new quinolones were also high among these isolates. the molecular characterization of ciprofloxacin-resistant E coli showed that most of them have a double mutation in the gyrA gene associated with a single mutation in the parC gene. the Klebsiella pneumoniae isolates studied demonstrated high resistance rates to beta-lactam drugs, including broad-spectrum cephalosporins. the carbapenems were the compounds with the highest susceptibility rate among these isolates (100.0% susceptible) followed by cefepime (91.7% susceptible). Meropenem, imipenem and cefepime were also the most active drugs against Enterobacter spp. Among P. aeruginosa isolates, meropenem (MIC50, 2 mg/L) was the most active compound, followed by imipenem (MIC50, 4 mg/L), cefepime (MIC50, 8 mg/L) end ceftazidime (MIC50, 16 mg/L). the results presented in this report confirm that bacterial resistance continues to be a great problem in Latin American medical institutions.
Idioma Inglês
Data de publicação 2000-03-01
Publicado em Journal of Antimicrobial Chemotherapy. Oxford: Oxford Univ Press, v. 45, n. 3, p. 295-303, 2000.
ISSN 0305-7453 (Sherpa/Romeo, fator de impacto)
Publicador Oxford Univ Press
Extensão 295-303
Fonte http://dx.doi.org/10.1093/jac/45.3.295
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000086244100005
Endereço permanente http://repositorio.unifesp.br/handle/11600/26254

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