Oral ciprofloxacin vs. intravenous ceftriaxone administered in an outpatient setting for fever and neutropenia in low-risk pediatric oncology patients: Randomized prospective trial

Oral ciprofloxacin vs. intravenous ceftriaxone administered in an outpatient setting for fever and neutropenia in low-risk pediatric oncology patients: Randomized prospective trial

Autor Petrilli, A. S. Google Scholar
Dantas, L. S. Google Scholar
Campos, M. C. Google Scholar
Tanaka, C. Google Scholar
Ginani, V. C. Google Scholar
Seber, A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Background. infections are one of the major complications in children undergoing chemotherapy. Monotherapy with either ciprofloxacin or ceftriaxone is safe and efficient in low-risk patients (solid tumors and stage I/II lymphomas). the same drugs may be used in an outpatient setting, decreasing costs and the risk of nosocomial infections. Procedure. Low-risk patients (N = 70) with episodes of fever and neutropenia (N = 116) were randomized to receive either oral ciprofloxacin or intravenous ceftriaxone as outpatients. Only one patient had a central venous catheter. Results. Episodes of fever and neutropenia were classified as fever of unknown origin (41% vs. 32%) or clinically documented infection (56% vs. 63%) in the ciprofloxacin and ceftriaxone groups, respectively. Most of these infections were of upper respiratory tract, skin, or gastrointestinal origin. the mean duration of neutropenia was 5 vs. 6 days. Fever persisted for 1-9 days (mean 2 vs. 3 days). Therapy was successful with no modifications in 83% vs. 75% of the episodes. Patients were admitted in 7% vs. 4% of the episodes. No bone or joint side effects were seen in either group. All patients survived. Conclusions. Outpatient therapy with either oral ciprofloxacin or intravenous ceftriaxone for fever and neutropenia is effective and safe in pediatric patients with solid tumors and stage I/II non-Hodgkin lymphoma (low-risk patients). Med. Pediatr. Oncol. 34:87-91, 2000. (C) 2000 Wiley-Liss. Inc.
Palavra-chave ciprofloxacin
ceftriaxone
infections
fever
neutropenia
Idioma Inglês
Data de publicação 2000-02-01
Publicado em Medical and Pediatric Oncology. New York: Wiley-liss, v. 34, n. 2, p. 87-91, 2000.
ISSN 0098-1532 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 87-91
Fonte http://dx.doi.org/10.1002/(SICI)1096-911X(200002)34:2<87
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000085165400002
Endereço permanente http://repositorio.unifesp.br/handle/11600/26242

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