Fungal morphogenesis and virulence

Fungal morphogenesis and virulence

Autor San-Blas, G. Google Scholar
Travassos, L. R. Google Scholar
Fries, B. C. Google Scholar
Goldman, D. L. Google Scholar
Casadevall, A. Google Scholar
Carmona, A. K. Google Scholar
Barros, T. F. Google Scholar
Puccia, R. Google Scholar
Hostetter, M. K. Google Scholar
Shanks, S. G. Google Scholar
Copping, VMS Google Scholar
Knox, Y. Google Scholar
Gow, NAR Google Scholar
Instituição Inst Venezolano Invest Cient
Universidade Federal de São Paulo (UNIFESP)
Albert Einstein Coll Med
Dept Biofis
Yale Univ
Univ Aberdeen
Resumo Phenotypic variability in pathogenic fungi has long been correlated with virulence, but specific genetic and molecular mechanisms are only recently being unraveled. Fungal morphogenesis, reflecting the expression of several regulated genes, and the capacity of the rising forms or phases to cause disease has been focused on at the XIVth Congress of the International Society for Human and Animal Mycology. Three experimental models of pathogenic fungi have been discussed. in Cryptococcus neoformans, phenotypic variability or switching represents controlled and programmed changes rather than random mutations. Evaluated phenotypic traits were the capsular polysaccharide, cell and colony morphology and virulence. in the dimorphic Paracoccidioides brasiliensis, the serine-thiol proteinase from the yeast phase cleaves the main components of the basal membrane, thus being potentially relevant in fungal dissemination. in Candida albicans, relationships between adhesion proteins and those of lymphocytes and neutrophils are related to fungal pathogenicity. Regulation of the directional growth of hyphae and its tropic responses are correlated with the invasive potential of C. albicans.
Palavra-chave Candida albicans
Cryptococcus neoformans
Paracoccidioides brasiliensis
Idioma Inglês
Data de publicação 2000-01-01
Publicado em Medical Mycology. Oxford: B I O S Scientific Publishers Ltd, v. 38, p. 79-86, 2000.
ISSN 1369-3786 (Sherpa/Romeo, fator de impacto)
Publicador B I O S Scientific Publishers Ltd
Extensão 79-86
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000166958800010
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