Patients with head and neck tumors excrete a chondroitin sulfate with a low degree of sulfation: A new tool for diagnosis and follow-up of cancer therapy

Patients with head and neck tumors excrete a chondroitin sulfate with a low degree of sulfation: A new tool for diagnosis and follow-up of cancer therapy

Autor Martins, João RM Autor UNIFESP Google Scholar
Gadelha, Maria EC Autor UNIFESP Google Scholar
Fonseca, Sonia M. Autor UNIFESP Google Scholar
Sampaio, Lucia O. Autor UNIFESP Google Scholar
Pontes, Paulo AL Autor UNIFESP Google Scholar
Dietrich, Carl P. Autor UNIFESP Google Scholar
Nader, Helena Bonciani Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The chondroitin sulfate excreted in the urine of 10 patients with cancer of the head and neck and 27 healthy subjects was analyzed. the disaccharide products formed from chondroitin sulfate excreted by these 10 patients by action of chondroitinase ABC show a significant (P < 0.0001) relative increase of nonsulfated disaccharide (35.6% +/- 5.7%) when compared with the nonsulfated disaccharide (10.0% +/- 0.9%) present in the chondroitin sulfate of 27 healthy subjects. in 6 patients the structure of the excreted compound was analyzed up to 4 months after surgery. After removal of the cancer, the percent amounts of the nonsulfated disaccharide tend to approach the values found for the chondroitin sulfate of healthy subjects. A significant (P < 0.0001) change in the ratio of urinary chondroitin sulfate and heparan sulfate and a decrease in the electrophoretic migration of chondroitin sulfate were also observed. All of the patients with head and neck cancer analyzed so far have shown this structural anomaly of urinary chondroitin sulfate. This assay may be useful in the diagnosis and follow-up of cancer therapy.
Idioma Inglês
Data de publicação 2000-01-01
Publicado em Otolaryngology-head and Neck Surgery. St Louis: Mosby-year Book Inc, v. 122, n. 1, p. 115-118, 2000.
ISSN 0194-5998 (Sherpa/Romeo, fator de impacto)
Publicador Mosby-year Book Inc
Extensão 115-118
Fonte http://dx.doi.org/10.1016/S0194-5998(00)70158-6
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000084768300025
Endereço permanente http://repositorio.unifesp.br/handle/11600/26221

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