Influence of cholecalciferol (vitamin D3) on the course of experimental systemic lupus erythematosus in F1 (NZBxW) mice

Influence of cholecalciferol (vitamin D3) on the course of experimental systemic lupus erythematosus in F1 (NZBxW) mice

Autor Vaisberg, M. W. Google Scholar
Kaneno, R. Google Scholar
Franco, M. F. Google Scholar
Mendes, N. F. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ Marilia
Resumo The course of systemic lupus erythematosus (SLE), an autoimmune disease, is markedly affected by hormones such as estrogen and prolactin. It is well known that heavy exposure to sunlight has deleterious effects on SLE, triggering episodes of the disease. Classical explanations for this occurrence suggest that UV radiation damages DNA, which becomes immunogenic, or induces exposure of the Ro antigen in keratinocytes. in recent years, it has been shown that vitamin D3 has important effects on the immune system. Thus, we proposed an alternative hypothesis, suggesting that UV radiation, by promoting vitamin D3 synthesis, could be a factor aggravating the course of SLE after exposure to sunlight. To test this hypothesis, we injected F1(NZBxW) mice, which are prone to developing SLE, with vitamin D3, and we demonstrated a worsening of the histopathological findings in the kidney. (C) 2000 Wiley-liss, Inc.
Palavra-chave lupus nephritis
vitamin D3
hormones
autoimmune disease
ultraviolet radiation
Idioma Inglês
Data de publicação 2000-01-01
Publicado em Journal of Clinical Laboratory Analysis. New York: Wiley-liss, v. 14, n. 3, p. 91-96, 2000.
ISSN 0887-8013 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 91-96
Fonte http://dx.doi.org/10.1002/(SICI)1098-2825(2000)14:3<91
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000086765000002
Endereço permanente http://repositorio.unifesp.br/handle/11600/26211

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