Cell damage and neurogenesis in the dentate granule cell layer of adult rats after pilocarpine- or kainate-induced status epilepticus

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dc.contributor.author Covolan, Luciene [UNIFESP]
dc.contributor.author Ribeiro, LTC
dc.contributor.author Longo, B. M.
dc.contributor.author Mello, LEAM
dc.date.accessioned 2016-01-24T12:30:58Z
dc.date.available 2016-01-24T12:30:58Z
dc.date.issued 2000-01-01
dc.identifier http://dx.doi.org/10.1002/(SICI)1098-1063(2000)10:2<169
dc.identifier.citation Hippocampus. New York: Wiley-liss, v. 10, n. 2, p. 169-180, 2000.
dc.identifier.issn 1050-9631
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/26210
dc.description.abstract Dentate granule cells are generally considered to be relatively resistant to excitotoxicity and have been associated with robust synaptogenesis after neuronal damage. Synaptic reorganization of dentate granule cell axons, the mossy fibers, has been suggested to be relevant for hyperexcitability in human temporal lobe epilepsy and animal models. A recent hypothesis suggested that messy-fiber sprouting is dependent on newly formed dentate granule cells. However, we recently demonstrated that cycloheximide (CHX) can block the messy-fiber sprouting that would otherwise be induced by different epileptogenic agents and does not interfere with epileptogenesis in those models. Here, we investigated cell damage and neurogenesis in the dentate gyrus of pilocarpine- or kainate-treated animals with or without coadministration of CHX. Dentate granule cells were highly vulnerable to pilocarpine induced-status epilepticus (SE), but were hardly damaged by kainate-induced SE. CHX pretreatment markedly reduced the number of injured neurons after pilocarpine-induced SE. Induction of SE dramatically increased the mitotic rate of KA-and KA + CHX-treated animals. Induction of SE in animals injected with pilocarpine alone led to 2-7-fold increases in the mitotic rate of dentate granule cells as compared to 5- and 30-fold increases for pilocarpine + CHX animals. We suggest that such increased mitotic rates might be associated with a protection of a vulnerable precursor cell population that would otherwise degenerate after pilocarpine-induced SE. We further suggest that messy-fiber sprouting and neurogenesis of granule cells are not necessarily linked to one another. (C) 2000 Wiley-Liss, Inc. en
dc.format.extent 169-180
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Hippocampus
dc.rights Acesso restrito
dc.subject cell damage en
dc.subject cell division en
dc.subject epilepsy en
dc.subject dentate gyrus en
dc.subject mossy fiber sprouting en
dc.title Cell damage and neurogenesis in the dentate granule cell layer of adult rats after pilocarpine- or kainate-induced status epilepticus en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Physiol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Physiol, BR-04023900 São Paulo, Brazil
dc.identifier.doi 10.1002/(SICI)1098-1063(2000)10:2<169
dc.description.source Web of Science
dc.identifier.wos WOS:000086611000005



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