Neonatal monosodium glutamate treatment alters rat intestinal muscle reactivity to some agonists

Exibir registro simples

dc.contributor.author Sukhanov, S. N.
dc.contributor.author Andrade, I. S. de
dc.contributor.author Dolnikoff, M. S.
dc.contributor.author Ferreira, A. T.
dc.date.accessioned 2016-01-24T12:30:57Z
dc.date.available 2016-01-24T12:30:57Z
dc.date.issued 1999-12-15
dc.identifier http://dx.doi.org/10.1016/S0014-2999(99)00751-7
dc.identifier.citation European Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 386, n. 2-3, p. 247-252, 1999.
dc.identifier.issn 0014-2999
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/26196
dc.description.abstract The following study is an investigation of the changes in the contractile reactivity of visceral muscles in response to agonists and alterations in metabolic parameters after neonatal rat treatment with monosodium-L-glutamate. This treatment markedly sensitizes ileum and colon preparations to adenosine-5'-triphosphate (ATP) stimulation and also increases the colon activity to acetylcholine (p < 0.05). Response to bradykinin remained unchanged, while ileum activity to angiotensin II was characterized by a reduction in the maximal tension (E-max) and an increase in the EC50 (p < 0.05) value. the responses of nonintestinal muscle preparations from monosodium-glutamate-treated rats to both ATP and bradykinin did not show a significant difference when compared to the controls. This treatment diminished food intake, feces excretion and increased plasma insulin, nonesterified fatty acids and triglyceride concentrations(p < 0.001). These results suggest that the changes in intestinal muscle activity, in response to agonists, can be due to metabolic alterations as well as the monosodium glutamate action on enteric neurons and/or smooth muscle receptors. (C) 1999 Elsevier Science B.V. All rights reserved. en
dc.format.extent 247-252
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof European Journal of Pharmacology
dc.rights Acesso restrito
dc.subject monosodium glutamate en
dc.subject smooth muscle en
dc.subject adenosine-5 '-triphosphate en
dc.subject acetylcholine en
dc.subject bradykinin en
dc.subject angiotensin II en
dc.title Neonatal monosodium glutamate treatment alters rat intestinal muscle reactivity to some agonists en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Biophys, BR-04023062 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Physiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Biophys, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Physiol, BR-04023062 São Paulo, Brazil
dc.identifier.doi 10.1016/S0014-2999(99)00751-7
dc.description.source Web of Science
dc.identifier.wos WOS:000084502700015



Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Exibir registro simples

Buscar


Navegar

Minha conta