Neonatal monosodium glutamate treatment alters rat intestinal muscle reactivity to some agonists

Neonatal monosodium glutamate treatment alters rat intestinal muscle reactivity to some agonists

Autor Sukhanov, S. N. Google Scholar
Andrade, I. S. de Google Scholar
Dolnikoff, M. S. Google Scholar
Ferreira, A. T. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The following study is an investigation of the changes in the contractile reactivity of visceral muscles in response to agonists and alterations in metabolic parameters after neonatal rat treatment with monosodium-L-glutamate. This treatment markedly sensitizes ileum and colon preparations to adenosine-5'-triphosphate (ATP) stimulation and also increases the colon activity to acetylcholine (p < 0.05). Response to bradykinin remained unchanged, while ileum activity to angiotensin II was characterized by a reduction in the maximal tension (E-max) and an increase in the EC50 (p < 0.05) value. the responses of nonintestinal muscle preparations from monosodium-glutamate-treated rats to both ATP and bradykinin did not show a significant difference when compared to the controls. This treatment diminished food intake, feces excretion and increased plasma insulin, nonesterified fatty acids and triglyceride concentrations(p < 0.001). These results suggest that the changes in intestinal muscle activity, in response to agonists, can be due to metabolic alterations as well as the monosodium glutamate action on enteric neurons and/or smooth muscle receptors. (C) 1999 Elsevier Science B.V. All rights reserved.
Assunto monosodium glutamate
smooth muscle
adenosine-5 '-triphosphate
angiotensin II
Idioma Inglês
Data 1999-12-15
Publicado em European Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 386, n. 2-3, p. 247-252, 1999.
ISSN 0014-2999 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 247-252
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000084502700015

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