Preliminary characterization of a Kazal-type serine protease inhibitor from Caiman crocodilus yacare plasma

Preliminary characterization of a Kazal-type serine protease inhibitor from Caiman crocodilus yacare plasma

Author Araujo, Mariana S. Autor UNIFESP Google Scholar
Nunes, Viviane A. Autor UNIFESP Google Scholar
Gozzo, Andrezza Justino Autor UNIFESP Google Scholar
Sampaio, Misako U. Autor UNIFESP Google Scholar
Auerswald, Ennes Google Scholar
Ura, Nobuyuki Google Scholar
Shimamoto, Kazuaki Google Scholar
Sampaio, Claudio AM Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Innenstadt LMU Munchen
Sapporo Med Univ
Abstract Blood serine protease inhibitors are becoming better understood and increasingly applied in blood clotting, cancer and other diseases. Reptiles are suitable models for blood coagulation and related processes, moreover, caiman is a good comparative model of a non-poisonous reptile. Recently, we reported the purification of a kininogen, the presence of proteases involved in blood clotting, and a serine protease inhibitor in Caiman crocodilus yacare plasma. in this paper, we described the partial sequence of an inhibitor (CcTI). the inhibitor is an 80-kDa protein, and it inactivates trypsin and chymotrypsin the hydrolysis of specific chromogenic substrates and in the degradation of gelatin. the inhibitor is member of Kazal-type inhibitor family and consists of several domains, its putative reactive: site is Arg-His. (C) 1999 Elsevier Science B.V. All rights reserved.
Keywords serine protease inhibitor
amino terminal sequence
reptile
Kazal inhibitor
Language English
Date 1999-12-01
Published in Immunopharmacology. Amsterdam: Elsevier B.V., v. 45, n. 1-3, p. 179-183, 1999.
ISSN 0162-3109 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 179-183
Origin http://dx.doi.org/10.1016/S0162-3109(99)00145-9
Access rights Closed access
Type Article
Web of Science ID WOS:000084080100029
URI http://repositorio.unifesp.br/handle/11600/26191

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