Preliminary characterization of a Kazal-type serine protease inhibitor from Caiman crocodilus yacare plasma

Preliminary characterization of a Kazal-type serine protease inhibitor from Caiman crocodilus yacare plasma

Autor Araujo, M. S. Google Scholar
Nunes, V. A. Google Scholar
Gozzo, A. J. Google Scholar
Sampaio, M. U. Google Scholar
Auerswald, E. Google Scholar
Ura, N. Google Scholar
Shimamoto, K. Google Scholar
Sampaio, CAM Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Innenstadt LMU Munchen
Sapporo Med Univ
Resumo Blood serine protease inhibitors are becoming better understood and increasingly applied in blood clotting, cancer and other diseases. Reptiles are suitable models for blood coagulation and related processes, moreover, caiman is a good comparative model of a non-poisonous reptile. Recently, we reported the purification of a kininogen, the presence of proteases involved in blood clotting, and a serine protease inhibitor in Caiman crocodilus yacare plasma. in this paper, we described the partial sequence of an inhibitor (CcTI). the inhibitor is an 80-kDa protein, and it inactivates trypsin and chymotrypsin the hydrolysis of specific chromogenic substrates and in the degradation of gelatin. the inhibitor is member of Kazal-type inhibitor family and consists of several domains, its putative reactive: site is Arg-His. (C) 1999 Elsevier Science B.V. All rights reserved.
Palavra-chave serine protease inhibitor
amino terminal sequence
reptile
Kazal inhibitor
Idioma Inglês
Data de publicação 1999-12-01
Publicado em Immunopharmacology. Amsterdam: Elsevier B.V., v. 45, n. 1-3, p. 179-183, 1999.
ISSN 0162-3109 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 179-183
Fonte http://dx.doi.org/10.1016/S0162-3109(99)00145-9
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000084080100029
Endereço permanente http://repositorio.unifesp.br/handle/11600/26191

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